Malaria case study

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What is malaria?

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1

What is malaria?

  • a tropical, water-borne disease that is biologically transmitted by female anopheles mosquitoes

  • it is caused by parasites of the Plasmodium family

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2

What group is the most at risk from malaria?

Children under 5- in 2018 they accounted for 67% of malaria deaths worldwide and it is estimated malaria kills one child every minute worldwide

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3

Are deaths due to malaria decreasing (statistics)?

Yes, for example:

  • in 2018 there were an estimated 405,000 deaths caused by malaria in comparison to 585,000 in 2010

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4

How many people is malaria estimated to have killed throughout history?

Malaria is estimated to have killed over half the people who have ever lived on Earth.

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5

In what reigon is malaria most prevalent?

Africa

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6

In what reigons is malaria least prevalent?

Europe and the Americas

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7

How is the spread of malaria related to the physical environment?

  • mosquitos breed in stagnant water meaning transmission is higher in areas close to large bodies of water of after/during the rainy season

  • parasites require temperatures of 16 to 32 degrees celsius inside the mosquito which conenctrates disease in tropics

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8

How is the incidence of malaria related to the socio-economic envrionment?

  • referred to as the 'disease of poverty'

  • when measured as DALYs, 58% of total global burden due to malaria is concentrated in poorest 20% of population

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9

What are nine socio-economic factors that can increase the incidence of malaria?

income, age and gender, ethnicity, occupation, healthcare accessibility, education, sanitation, housing quality, rural vs. urban environments

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10

What is the definition of well-being?

The state of being comfortable, healthy or happy.

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11

What are four impacts of malaria on economic well-being (including to the government and to the individual)?

  • Purchase of anti-malarial drugs, treatment supplies and prevention measures

  • Abscence from school and work

  • Reduction in subsistence crop production

  • Expense of burial

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12

What overall effects do these impacts have on the economy?

  • Slow economic growth

  • Slow rates of development

  • A prolonged cycle of poverty

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13

What are three strategies to reduce malarial infection?

  • Prevention

  • Management

  • Eradication

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14

What are ways to incorporate management and prevention?

  • Physical barrier like IRS nets and chemical barriers like preventative treatment during pregnancy

  • Investment in 'swift' diagnosis

  • Drug treatment of disease using Artemisinin-based combination therapies (ACTs)

  • Control of vector using insecticides

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15

What are some NGOs that work to combat malaria?

  • Bill and Melinda Gates Foundation

  • The WHO

  • The US President's malaria intiative -Malaria no more charity

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16

How does the Bill and Melinda Gates foundation work to combat malaria?

They pursue a 'Pathway to Eradication' using the following strategies:

  • Optimise coverage of chemoprevention

  • Support next generation surveillance and data use with an emphasis on scaling genetic epidemiology

  • Work in high burden countries to rapidly reduce deaths through data-driven systems (aligned with High Burden to High Impact initiative launched by the WHO in November 2018)

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17

What is the general role of NGOs and international agencies in combating malaria (funding)?

  • Global financing of malaria control programmes increased from US$90 million to US$2.5 billion between 2005-2015

  • Bill and Melinda Gates Foundation contributed $1.6 billion to the global fund and $2 billion in grants

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18

What are the Millennium Development Goals and how do they relate to malaria?

  • Goals set up by the UN to improve quality of life across the world

  • Goal 6c is halting and beginning to reverse the incidence of malaria by 2015

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19

Why was the 6c MDG successful?

Yes:

  • the incidence rate of malaria decreased by 37% between 2000 and 2015 per 1000 people at risk

  • proportion of children sleeping under IRS nets and being treated for fever with anti-malarial drugs increased by over 100% between 2000 and 2015

  • 58% decline in malaria mortality rates globally

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20

Why was the 6c MDG unsuccessful?

In most cases, it failed to halt the incidence of malaria, just to reduce it/manage it.

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21

How does housing quality and occupancy affect the incidence of malaria?

  • Windows in poor-quality housing are uncovered so don't protect against mosquitoes

  • Densely populated houses mean easier transmission

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22

How do unsanitary conditions increase the incidence of malaria?

  • Malarial 'hotspots' are often dirty and crowded public places, where mosquitoes are attracted by wastewater outflows, open defecation and spitting

  • For example: Chennai in southern India

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23

How does occuptaion increase the incidence of malaria?

  • Agricultural workers are often near large stores of irrigation water where mosquitoes can breed.

  • Migrant workers often sleep outside and are more exposed to mosquitoes.

  • For example: studies in Ethiopia found highland farmers who seasonally migrate to lowland areas are very prone to malaria

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24

How do age and gender increase the incidence of malaria?

  • Children under five are thought to be the most prone

  • For example: studies in Tanzania and Gambia indicate children aged 5-14 are most at risk now due to more focus on prevention in younger age groups

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25

How does ethnicity increase the incidence of malaria?

  • It can mean different attitudes towards health and education, especially when looking at treatment

  • For example: non-Thais searching for work in Thailand have greater malaria exposure

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26

How do rural vs. urban environments increase the incidence of malaria?

  • Rural areas tend to be more vulnerable (generally less education, further from healthcare facilities etc.)

  • However, urban areas often have high infection rates due to poor sanitation and dense populations

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27

How does (low) income increase the incidence of malaria?

  • Low-income groups tend to spend less on preventative measures and have poor nourishment so cerebral malaria is common, especially among children

  • Disproportionately affects agricultural workers who often earn a small, seasonal salary (no money for prevention in malarial season)

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28

How does (lack of) education increase the incidence of malaria?

  • those with less education tend to lack understanding of the causes of malaria and are less likely or less able to invest in preventative measures

  • For example: studies in Malawi found net ownership was largely absent in households where the head hadn't completed primary education

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29

How does distance and accessibility of healthcare affect the incidence of malaria?

  • Greater distance to nearest clinics/hospitals means fewer seek treatment or prevention and methods are employed less frequently

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30

Where is Uganda located?

Uganda is located in East Africa, bordering Kenya, Ethiopia, Tanzania, Kigali and the DRC

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31

What were the statistics for malaria in Uganda in 2015?

  • 3.6 million cases of malaria

  • almost 6000 deaths

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32

Why does Uganda experience year round transmission?

  • Equatorial climate with high temperatures (constant at about 22.5 degrees Celsius) and lots of rainfall

  • Lots of large bodies of water (e.g. Lake Victoria) with high population densities

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33

What other factors (non environmental) cause Uganda to suffer from malaria?

  • Poor country with limited access to resources, with 37.8% of the population living on less than $1.25 per day

  • Mosquitoes are becoming resistant to insecticides

  • Insecticide-treated nets are not used properly

  • Population density is concentrated around large bodies of water

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34

How is Uganda combatting malaria?

  • Improved drainage and irrigation in rural areas

  • Afro Alpine Pharma factory opened in 2009 to grow locally produced anti-malarial drugs at a cheaper cost and employs more than 5,000 farmers

  • A focus on early diagnosis and prompt treatment

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