Neurotransmitter & inhibitory GABA-ergic synapse

How does an inhibitory GABA-ergic synapse differ from an excitatory cholinergic synapse?

In an inhibitory GABA-ergic synapse, the neurotransmitter GABA binds to ligand-gated Cl- channels, causing Cl- to enter the cell, making the inside more negative and inhibiting the neuron from firing action potentials.

What happens when chloride (Cl-) enters the cell during an inhibitory GABA-ergic synapse?

The inside of the cell becomes more negative, making it less likely that the neuron will reach the threshold potential to generate an action potential.

How can neurotransmitter signaling be stopped in the synapse?

Neurotransmitters can be removed by degradation, reuptake, or diffusion.

What is neurotransmitter degradation?

is the breakdown of neurotransmitters by enzymes

What is reuptake in neurotransmitter disposal?

is when neurotransmitters are transported back into the presynaptic neuron for reuse or degradation.

How does diffusion contribute to the cessation of neurotransmitter signaling?

Neurotransmitters diffuse out of the synaptic cleft, reducing their presence and ceasing the signal.