microbio unit 15G: microbial diseases of the nervous + cardiovascular systems

II: microbial diseases of the cardiovascular system (SEPTICEMIA, PUERPERAL SEPSIS/FEVER, ENDOCARDITIS, RHEUMATIC FEVER)

septicemia

microbial growth or toxins in the blood

what are the symptoms of septicemia?

fever

drop in blood pressure

O₂ decrease

vessel constriction

shock

death

_____, drop in blood pressure, ___ decrease, vessel constriction, shock, and ____ are symptoms of septicemia

fever

drop in blood pressure

O₂ decrease

vessel constriction

shock

death

septicemia is usually what type of infection?

focal

what is meant by “focal” infection?

infection that starts in one specific part of the body (a focus) then spreads to other areas

what types of gram microbes can cause septicemia?

gram ±

→ produce endotoxins

septicemia is often accompanied by what symptom?

lymphangitis → lymph vessels under the skin become inflamed

what is the mortality rate of septicemia?

28%-50%

puerperal sepsis/fever is a ______ infection

uterine

what microbe is responsible for puerperal sepsis/fever

s. pyogenes

puerperal sepsis/fever is usually _________

nosocomial

puerperal sepsis/fever is is the result of what?

childbirth or an abortion

endocarditis (subacute bacterial endocarditis or SBE) is due to what microbe?

streptococcus sp.

subacute bacterial endocarditis is usually a _____ infection

focal

endocarditis

infection of the inner lining of the heart → mainly affects the heart valves

acute bacterial endocarditis

rapid destruction of the heart valves

acute bacterial endocarditis is caused by what microbe?

staphylococcus

what is the difference between subacute and acute bacterial endocarditis?

subacute caused by streptococcus

acute caused by staphylococcus

rheumatic fever is a type ___ immune complex disease

III

untreated s. ________ throat infections lead to rheumatic fever

s. pyogenes

what % of s. pyogenes throat infections leads to rheumatic fever?

3%

rheumatic fever is a ______ infection

sequelae

when does rheumatic fever occur post-streptococcal pyogenes infection?

1-5 weeks after the infection

what are the symptoms of rheumatic fever?

fever

arthritis

inflammation of the heart → permanent damage

the symptoms of rheumatic fever are fever, _______, and inflammation of the ______, leading to permanent damage

fever

arthritis

inflammation of the heart → permanent damage

what population is most affected by rheumatic fever?

children ages 4-18 years old