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A comprehensive vocabulary set covering key structures, pathways, cranial nerves, and clinical terms from the Motor Speech Disorders neurology review.
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Central Nervous System (CNS)
The brain and spinal cord, responsible for integrating and coordinating all nervous functions.
Peripheral Nervous System (PNS)
All neural structures outside the CNS, including 12 cranial nerves and 31 spinal nerves.
Pyramidal Tract
Major CNS pathway containing most cortical motor neurons; mediates voluntary, fine motor control.
Purkinje Cells
Large inhibitory neurons of the cerebellar cortex that refine motor output.
Brainstem
Midbrain, pons, and medulla; houses cranial nerve nuclei III–XII and vital centers.
Corticospinal Pathway
UMN tract from motor cortex to spinal nerves; controls limb and trunk movements.
Corticobulbar Pathway
UMN tract from cortex to brainstem cranial nerve nuclei; controls face, head, and neck muscles.
Neurons
Electrochemically active cells that transmit signals; functional units of the nervous system.
Cell Body (Soma)
Gray-matter portion of a neuron containing the nucleus and metabolic machinery.
Dendrite
Short projections that receive impulses from other neurons or sensory receptors.
Axon
Long fiber conducting impulses away from the soma toward muscles, glands, or other neurons.
Myelin
Fatty white sheath surrounding many axons, speeding impulse conduction.
Neuromuscular Junction
Synapse where a lower motor neuron communicates with a muscle fiber.
Gray Matter
Regions rich in neuron cell bodies, giving a gray appearance (e.g., cortex, nuclei).
White Matter
Myelinated axonal pathways that appear white; includes tracts and commissures.
Glial Cells
Supportive brain cells (e.g., astrocytes, oligodendroglia) that outnumber neurons.
Oligodendroglia
Glia that form myelin in the CNS.
Schwann Cells
Glia that form myelin in the PNS.
Astrocytes
Star-shaped glia aiding neuronal metabolism, repair, and blood–brain barrier maintenance.
Ependymal Cells
Cells lining ventricles; form choroid plexus and secrete cerebrospinal fluid.
Microglia
Phagocytic glia that transform into macrophages during CNS injury or infection.
Meninges
Three connective-tissue layers (dura, arachnoid, pia) protecting brain and spinal cord.
Pia Mater
Delicate inner meningeal layer adhering to brain surface; part of blood–brain barrier.
Arachnoid
Middle meningeal layer with web-like trabeculae and cerebrospinal-fluid circulation.
Dura Mater
Tough outer meningeal layer lining skull and brain fissures.
Epidural Space
Potential space between skull and dura; common site for hematoma.
Subdural Space
Space beneath dura; can fill with blood in head injury.
Subarachnoid Space
CSF-filled cavity beneath arachnoid surrounding brain and spinal cord.
Ventricular System
Interconnected brain cavities producing, circulating, and draining cerebrospinal fluid.
Anterior Cerebral Artery (ACA)
Supplies medial frontal and parietal lobes and anterior corpus callosum.
Middle Cerebral Artery (MCA)
Feeds lateral frontal, parietal, and superior temporal lobes; most common stroke site.
Basilar Artery
Midline brainstem vessel supplying pons and cerebellum.
Posterior Cerebral Artery (PCA)
Supplies occipital lobe, inferior temporal lobe, and thalamic regions.
Circle of Willis
Arterial ring connecting carotid and vertebrobasilar systems at brain base.
Carotid System
Anterior circulation via internal and external carotid arteries; often implicated in aphasia.
Motor System
Neural network converting thought into voluntary movement.
Primary Cortex
Initial cortical area for processing sensory input or generating motor output.
Association Cortex
Cortical areas that interpret sensory data and plan voluntary actions.
Basal Ganglia
Subcortical nuclei (caudate, putamen, globus pallidus) that regulate movement initiation and tone.
Cerebellum
Structure coordinating posture, balance, and timing of skilled movements; damage causes ataxia.
Thalamus
Relay nucleus transmitting sensory and processed motor information to cortex.
Pyramidal System (Direct)
Conscious motor pathway controlling skilled, discrete movements (corticospinal & corticobulbar).
Extrapyramidal System (Indirect)
Subconscious pathways regulating posture, tone, and automatic movements.
Upper Motor Neuron (UMN)
Motor fibers within CNS; lesions cause spasticity and hyperreflexia.
Lower Motor Neuron (LMN)
Motor fibers of cranial and spinal nerves; lesions cause flaccid paralysis and atrophy.
Direct Activation Pathway
Another term for pyramidal system; delivers motor commands directly to LMNs.
Indirect Activation Pathway
Extrapyramidal routes that modulate LMNs via brainstem and basal ganglia circuitry.
Final Common Pathway
LMNs whose axons actually contact muscles; last link in motor execution.
Corticopontine Tract
Pyramidal fibers projecting to pontine nuclei en route to cerebellum.
Babinski Sign
Pathological dorsiflexion of big toe indicating corticospinal tract damage.
Hypokinesia
Reduced movement, often due to basal ganglia dopamine deficiency (e.g., Parkinson disease).
Hyperkinesia
Excess involuntary movement from basal ganglia dysfunction (e.g., chorea, dystonia).
Ataxia
Uncoordinated movement resulting from cerebellar lesions.
Homunculus
Somatotopic map on primary motor and sensory cortices representing body parts.
Trigeminal Nerve (CN V)
Mixed nerve providing facial sensation and mastication muscle control.
Facial Nerve (CN VII)
Mixed nerve for facial expression, taste (anterior 2/3 tongue), and salivary glands.
Glossopharyngeal Nerve (CN IX)
Mixed nerve for stylopharyngeus motor, posterior 1/3 tongue taste, and swallow onset.
Vagus Nerve (CN X)
Mixed nerve innervating palate, pharynx, larynx; key for voice and swallowing.
Accessory Nerve (CN XI)
Motor nerve to sternocleidomastoid and trapezius; aids head turn and shoulder shrug.
Hypoglossal Nerve (CN XII)
Motor nerve controlling intrinsic and extrinsic tongue muscles (except palatoglossus).
UMN Facial Palsy
Contralateral lower-face weakness sparing upper face due to cortical lesion.
LMN Facial Palsy
Ipsilateral total facial weakness with atrophy and fasciculations (e.g., Bell palsy).
Trigeminal Neuralgia
Sudden, severe facial pain along one trigeminal branch (V1, V2, or V3).
Phrenic Nerve
C3–C5 spinal nerve branch innervating the diaphragm for respiration.
Ansa Cervicalis
C1–C3 loop supplying infrahyoid muscles; sometimes used in laryngeal reinnervation.
Decerebrate Posture
Extensor-rigid positioning indicating brainstem lesion below red nucleus.
Decorticate Posture
Flexed upper limbs with extended legs signaling lesion above red nucleus.
Babinski Reflex
Plantar reflex variant where dorsiflexed Hallux in adults signals UMN damage.
Cerebrocerebellum
Lateral cerebellar hemisphere region implicated in planning and coordination of movement.
Genioglossus
Extrinsic tongue muscle protruding tongue; innervated contralaterally by CN XII.
Suprahyoid Muscles
Muscles above hyoid (e.g., mylohyoid) elevating hyoid and aiding jaw opening.
Infrahyoid Muscles
Muscles below hyoid that depress or stabilize it; innervated by ansa cervicalis.
Intrinsic Tongue Muscles
Muscles altering tongue shape (e.g., superior longitudinal); all CN XII.
Extrinsic Tongue Muscles
Muscles moving tongue position (e.g., styloglossus); mostly CN XII.
Corticobulbar Tract Damage
Produces spasticity or flaccidity in cranial-nerve-supplied muscles, affecting speech.
Extrapyramidal Lesion
Causes involuntary movements (dyskinesias) or altered muscle tone.
Hypesthesia
Reduced sensation; may follow trigeminal nerve lesion.
Fasciculations
Involuntary LMN muscle twitches indicating denervation.
Atrophy
Muscle wasting due to LMN loss or disuse.
Pyramidal Decussation
Crossing of corticospinal fibers in medulla leading to contralateral limb control.
Internal Capsule
White-matter structure containing all cortical afferent and efferent projections.
Cranial Nerve Modalities
Categories of function: general sensory, visceral sensory, special sensory, somatic motor, branchial motor, visceral motor.