14 - NUCLEOTIDE METABOLISM 2025

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10 Terms

1
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Rate-limiting enzyme of purine synthesis

PRPP glutamyl amidotransferase

2
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Rate-limiting enzyme of pyrimidine synthesis

Carbamoyl phosphate synthetase II

3
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Atom donors of purine molecules

Glutamine, Aspartate, Carbon dioxide, Glycine, N10-formyltetra-hydrofolate

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Atom donors of pyrimidine molecules

Glutamine, Aspartate, Carbon dioxide

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Donor of ribose-5-phosphate involved in purine and pyrimidine synthesis

Phosphoribosyl pyrophosphate (PRPP)

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Structural analogs of PABA that competitively inhibit dihydropteroate synthase

Sulfonamides

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Structural analog of folate, selectively inhibits bacterial dihydrofolate reductase

Trimethoprim

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Metabolically converted to 5-FdUMP, which inhibits thymidylate synthase

5-fluorouracil

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Inhibits dihydrofolate reductase, which reduces the tetrahydrofolate supply for the synthesis of thymine

Methotrexate

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Reversible inhibitor of IMP dehydrogenase, depriving T and B lymphocytes of nucleic acids

Mycophenolate