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Rate-limiting enzyme of purine synthesis
PRPP glutamyl amidotransferase
Rate-limiting enzyme of pyrimidine synthesis
Carbamoyl phosphate synthetase II
Atom donors of purine molecules
Glutamine, Aspartate, Carbon dioxide, Glycine, N10-formyltetra-hydrofolate
Atom donors of pyrimidine molecules
Glutamine, Aspartate, Carbon dioxide
Donor of ribose-5-phosphate involved in purine and pyrimidine synthesis
Phosphoribosyl pyrophosphate (PRPP)
Structural analogs of PABA that competitively inhibit dihydropteroate synthase
Sulfonamides
Structural analog of folate, selectively inhibits bacterial dihydrofolate reductase
Trimethoprim
Metabolically converted to 5-FdUMP, which inhibits thymidylate synthase
5-fluorouracil
Inhibits dihydrofolate reductase, which reduces the tetrahydrofolate supply for the synthesis of thymine
Methotrexate
Reversible inhibitor of IMP dehydrogenase, depriving T and B lymphocytes of nucleic acids
Mycophenolate