PK Bioavalability and Half-Life (Lecture VII)
Call Kai
Learn
Practice Test
Spaced Repetition
Match
Flashcards
Knowt Play1/10
There's no tags or description
Looks like no tags are added yet.
Name | Mastery | Learn | Test | Matching | Spaced | Call with Kai |
|---|
No analytics yet
Send a link to your students to track their progress
11 Terms
Bioavailability
the rate and extent to which a drug administered in a dosage form enters systemic circulation
What is bioavailability described by?
peak plasma concentration
time to reach peak concentration
area under the curve (AUC)
What accounts for the major differences in dosages between species?
Bioavailablity
What does the disposition curve graphically define?
the time course of the drug in the plasma
How do you calculate bioavailability?
F = AUC(oral)/AUC(IV)
Absolute Bioavailability
IV versus non IV
Relative Bioavailability
non-IV versus non-IV
What is the rate of drug elimination (kel)?
fraction of drug eliminated per unit time
WHat is the elimination half-life?
the time required for the body to eliminated one-half of the drug from the blood
How do you calculate t1/2?
t1/2 = 0.693/kel
WHat influences half-life?
Vd
Clearance fro plasma
access of drug to organs
urinary pH
species
