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If a subcutaneous injection is to be given at a 90 degree angle, you should choos a needle that is ____ inches in length.
1/2
If a subcutaneous injection is to be given at a 45 degree angle, you should choos a needle that is ____ inches in length.
5/8
Therapeutic response
enough of a drug to produce the desired physiological response, but not enough to cause toxicity.
All _____ should be stored in a locked cabinet.
narcotics
narcotics should be _____ frequently, during the opening of narcotic drawers, and/or shift change.
counted
report discrepancies in narcotic counts _______.
immediately.
If you give only ____ of a premeasured dose of a controlled substance, a ____ nurse witnesses' disposal of the unused portion. ____ nurses sign their names on the required form.
part/second/Both
_____ is the passage of medication molecules into the blood from the site of administration.
Absorption
After a medication is absorbed, it is ______ to tissues and organs and finally to the site of drug action.
distributed
The rate and extent of distribution depends on _____ , cell membrane ______, and protein binding. When there is poor perfusion, as in the case of heart failure, this ____ medication distribution.
circulation/permeability/alters
After a medication reaches its site of action, it becomes ______ into a less active or inactive form.
metabolized
Most biotransformation occurs in the _____, although the lungs, kidneys, blood, and intestines also play a role.
liver
Patients (e.g., older adults and those with chronic disease) are at risk for ________ if their organs that metabolize medications do not function correctly.
medication toxicity
The final aspect of pharmacokinetics is ______, the process of medications exiting the body through the lungs, exocrine glands, bowel, kidneys, and liver.
excretion
A medication's _____ determines the organ of excretion. For example, gaseous and volatile compounds, such as alcohol and nitrous oxide, exit through the _____.
chemical makeup/lungs
en medications exit through sweat glands, you provide ______ to reduce skin irritation.
hygiene
You must know if a drug is excreted through the ______, because the administration of laxatives or enemas increases ______, accelerates excretion, and thus lessens the time for drug effects.
intestines/peristalsis
When patients have reduced renal function, they are at risk for medication toxicity.
renal
It is important to know the exact _______ for which a medication is prescribed so you can properly _____ patients about a medication's intended effect and to accurately evaluate the medication's desired effect.
therapeutic effect/teach
Sometimes a single medication has many therapeutic effects. For example, _____ relieves pain and reduces fever and tissue inflammation.
aspirin
________ are predictable and often unavoidable secondary effects produced at a usual therapeutic drug dose.
Side effects
some antihypertensive medications cause _______ in male patients.
impotence(side effect)
If the side effects are serious enough to outweigh the _____ of a medication's therapeutic action, the prescriber will likely _____ the medication.
benefits/discontinue
Patients commonly _____ taking medications because of side effects such as anorexia, nausea, vomiting, dizziness, drowsiness, dry mouth, constipation, and diarrhea.
stop
_____ drug effects are unintended, undesirable, and often unpredictable.
Adverse
Unfortunately, although ADEs are sometimes immediately apparent, they often take ___ or ____ to develop.
weeks/months
_____ recognition and reporting of ADEs will prevent serious injury to patients.
Prompt
_____ develop after prolonged intake of a medication, when a medication accumulates in the blood because of impaired metabolism or excretion, or when too high a dose is given.
Toxic effects
toxic levels of morphine, an opioid, cause severe _________ and death.
respiratory depression
Medications often cause unpredictable effects such as an _______ _______, in which a patient _______or _______to a medication or has a reaction different from normal.
idiosyncratic reaction/overreacts/underreacts
Predicting which patients will have an idiosyncratic response is _______.
impossible
Ativan, an antianxiety medication, when given to an older adult may cause ___________.
agitation and delirium(idiosyncratic reaction)
__________ also are unpredictable responses to a medication. Exposure to an initial dose of a medication causes a patient to become sensitized _______.
Allergic reactions/immunologically
The medication acts as an ____, which causes _______ to be produced. With repeated _________, the patient develops an allergic response to the drug, its chemical preservatives, or a metabolite.
antigen/antibodies/administration
Among the different classes of medications, ________ cause a high incidence of allergic reactions.
antibiotics
__ is fastest, directly into the blood stream.
IV
__ is second fastest, injected into muscle then absorbed into the bloodstream.
IM
__ is third fastest, injected into subcutaneous tissue, then absorbed slower than IM.
SQ
__ is slowest, swallowed by the patient, then goes through the stomach, then the first pass effect, then absorbed by the Digestive tract.
PO
The highest serum concentration (_____ concentration) of a medication usually occurs just before the body absorbs the ____ of the medication.
peak/last
With _________ infusions, the peak concentration occurs quickly, but the serum level also begins to fall ______.
intravenous (IV)/immediately
The point at which the lowest amount of drug is in the serum is the ______ concentration.
trough
A patient's trough level is drawn as a blood sample ________ before administering the drug, and the peak level is drawn whenever the drug is expected to reach its peak _____.
30 minutes/concentration
the 6 rights of medication
1The right medication, 2The right dose, 3The right patient, 4The right route, 5The right time, 6The right documentation