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What are the types of Adaptive Immunity?
CELL MEDIATED IMMUNITY
HUMORAL IMMUNITY
■ T cell immunity
CELL MEDIATED IMMUNITY
■ B cell immunity
■ ** works together, failure can alter its effectiveness
HUMORAL IMMUNITY
T cell
Arm of the adaptive immune response
Protects the host against infection by intracellular pathogens
Main function: destruction of microbes that survived in the cytoplasm or phagocytic vesicle of an infected cell
Can sometimes be harmful to host
Transplanted tissue and certain autoimmune diseases
CELL MEDIATED IMMUNITY
T cell
CELL MEDIATED IMMUNITY
Arm of the adaptive immune response
CELL MEDIATED IMMUNITY
Protects the host against infection by intracellular pathogens
CELL MEDIATED IMMUNITY
Main function: destruction of microbes that survived in the cytoplasm or phagocytic vesicle of an infected cell
CELL MEDIATED IMMUNITY
Can sometimes be harmful to host
Transplanted tissue and certain autoimmune diseases
CELL MEDIATED IMMUNITY
● B cell
● Mediated by antibody present in different body fluids or secretions (saliva, blood, vaginal secretions)
● Antibodies produced by B cells are very effective free floating and can be easily accessed and neutralized
● Migrate to the secondary lymphoid organ such as spleen and lymph nodes
HUMORAL IMMUNITY
● B cell
HUMORAL IMMUNITY
● Mediated by antibody present in different body fluids or secretions (saliva, blood, vaginal secretions)
HUMORAL IMMUNITY
● Antibodies produced by B cells are very effective free floating and can be easily accessed and neutralized
HUMORAL IMMUNITY
● Migrate to the secondary lymphoid organ such as spleen and lymph nodes
HUMORAL IMMUNITY
Phases of an Immune Response
RECOGNITION PHASE
AMPLIFICATON PHASE
EFFECTOR PHASE
TERMINATION PHASE
MEMORY
● Innate immune receptor binds to common molecular motifs on pathogens or Ab bound to invader
● Involves highly specific Ag
RECOGNITION PHASE
● Innate immune receptor binds to common molecular motifs on pathogens or Ab bound to invader
RECOGNITION PHASE
● Involves highly specific Ag
RECOGNITION PHASE
● involves complement cascade
● production of soluble factors (cytokines, acute phase reaction, etc) ● recruitment of army cells (WBC)- INNATE
● proliferation of B and T lymphocytes - ADAPTIVE
AMPLIFICATON PHASE
● involves complement cascade
AMPLIFICATON PHASE
● production of soluble factors (cytokines, acute phase reaction, etc) ● recruitment of army cells (WBC)- INNATE
AMPLIFICATON PHASE
● proliferation of B and T lymphocytes - ADAPTIVE
AMPLIFICATON PHASE
● results in the removal of antigens in different mechanism
● phagocytosis, neutralization, opsonization
EFFECTOR PHASE
● dampens the immune system after the antigen has been cleared
● critical phase
● for prevention of excessive responses that may harm the host (tissue damage)
TERMINATION PHASE
● dampens the immune system after the antigen has been cleared
TERMINATION PHASE
● critical phase
TERMINATION PHASE
● for prevention of excessive responses that may harm the host (tissue damage)
TERMINATION PHASE
● involves the generation of long lived B and T lymphocytes
● these cells have low threshold for activation and will react quickly
MEMORY
● involves the generation of long lived B and T lymphocytes
MEMORY
● these cells have low threshold for activation and will react quickly
MEMORY