TOPIC QUIZ: Drugs Dosage Forms & Delivery System

Select the cosmetics which are regulated as a drugs.

Skin protectants (lip balms and diaper ointments), Mouthwashes, Antiperspirants

Cosmetics is defined as:

Article for cleansing, beautifying, promoting attractiveness, or altering the appearance

What are the important considerations in the choice of excipients?

I. Cross-contamination.

II. Compatibility with the active drug

III. Effect on efficacy

IV. Cost of formulation

II, III, IV

Class III medical devices:

I.Pacemaker

II. Renal stent

III.High frequency ventilator

IV. Surgical glove

I, II and III

Classify the compounds with low solubility and high permeability, such that their bioavailability is limited by their solvation rate.

BCS class II

Classify compounds with low solubility and low permeability; poor bioavailability, these compounds are usually not well absorbed from the intestinal mucosa

BCS Class IV

Glibenclamide & Atorvastatin

BCS class II

Bifonazole

BCS Class IV

Cimetidine

BCS class III

BCS class eligible for a biowaiver

BCS class III and Ill

Select the method of preparing powders that consists of enclosing the powder in a container, which rotates and mixes the powder ingredients

Tumbling

Identify the method of preparing pharmaceutical powders which can be used to both comminute and blend the Ingredients

Trituration

Classification of chemical powder composed of particles that all pass through a No. 120 sieve classified

Very fine powder

Why are granules preferred over small particles for effervescent preparations?

Decreased rate of solution which prevents violent and uncontrollable effervescence

Identify the type of tablets that are prepared by compressing granular materials and have the capacity to release gas when in contact with water.

Effervescent tablets

Select the method of coating tablets that involves putting a thin, skin-tight, plastic-like material over the compressed tablet to produce coated tablets that have essentially the same weight, shape and size as the original compressed tablet

Film coating

Select the most appropriate solution for a capsule defect where the active ingredient dissolves in an acidic environment.

Coat the capsules with polyvinyl acetate phthalate

Dosage form that disintegrates and dissolves in the mouth, with creamy base for children and adults having a hard time swallowing large tablets

Chewable

Oval-shaped flat tablet that dissolves in the buccal pouch

Buccal

Identify the drug delivery system which achieves slow release of drug over an extended period of time

Sustained release

Determine the delivery system, which does not produce or maintain uniform drug levels. Within the therapeutic range, but is more effective for patient compliance than conventional dosage forms.

Delayed release

A capsule-shaped compressed tablet that allows the coated product to be about one-third smaller than a capsule filled with an equivalent amount of powder

Gelatin coated tablet

The following are disadvantages of formulating rapidly dissolving tablets except:

Rapid absorption

Type of mortar and pestle appropriate for staining materials

Glass

Which of the following is not a good characteristic of a suppository base?

Remains stable in rectal fluids

Suppositories

I. Vaginal

II. Rectal

III. Urethral

IV. Oral

I, II and III

The following are advantages of transdermal drug delivery systems, EXCЕРТ:

Not suitable for all drugs

Which of the following is classified as ointment bases?

I. Lanolin

II. Mineral oil

III. Petrolatum

IV. Glycerin

V. Coconut oil

I, III, V

Which of the following statements is correct about oleaginous ointment bases?

I. They include fixed oils of vegetable origin, fats from animals and semisolid HC obtained from petroleum

II. Vegetable oils and animal fats have lower water-absorbing capacity

III. Vegetable oils raise the melting point of ointments

IV. Oleaginous ointment bases are excellent emollients

I, II, IV

Classify the following ointment base

A. Hydrocarbon base

B. Absorption base

C. Water washable base

D. Water soluble base

E. Emulsifying base

F. Vegetable base

Olive oil 

F

Classify the following ointment base

A. Hydrocarbon base

B. Absorption base

C. Water washable base

D. Water soluble base

E. Emulsifying base

F. Vegetable base

Beeswax 

B

Classify the following ointment base

A. Hydrocarbon base

B. Absorption base

C. Water washable base

D. Water soluble base

E. Emulsifying base

F. Vegetable base

Soft paraffin 

A

Classify the following ointment base

A. Hydrocarbon base

B. Absorption base

C. Water washable base

D. Water soluble base

E. Emulsifying base

F. Vegetable base

PEG

D

Classify the following ointment base

A. Hydrocarbon base

B. Absorption base

C. Water washable base

D. Water soluble base

E. Emulsifying base

F. Vegetable base

Petrolatum

A

Classify the following ointment base

A. Hydrocarbon base

B. Absorption base

C. Water washable base

D. Water soluble base

E. Emulsifying base

F. Vegetable base

White petrolatum

A

Classify the following ointment base

A. Hydrocarbon base

B. Absorption base

C. Water washable base

D. Water soluble base

E. Emulsifying base

F. Vegetable base

Lanolin

B

Classify the following ointment base

A. Hydrocarbon base

B. Absorption base

C. Water washable base

D. Water soluble base

E. Emulsifying base

F. Vegetable base

Anhydrous lanolin

B

Choose the components of White Ointment

White wax & white petrolatum

Select the pair that are correctly matched

I. Peppermint water - Hydroalcoholic

II. Aromatic elixir Hydroalcoholic

III. Compound Cardamom Tincture - Alcoholic

IV. Simple Syrup - Aqueous

V. Orange Flower Water - Alcoholic

II, III, IV

Select the statements that best described syrups as diluting agents

I. Syrups are useful as diluting agents for water-insoluble drugs

II. Syrups act both as solvents and flavoring agents

III. Glycyrrhiza Syrup is an excellent vehicle for saline substances because of its colloidal properties, sweet flavor and licorice taste

IV. Aromatic Eriodictyon Syrup is the diluting agent of choice for masking taste of urea

II, III

Which kind of water is obtained by distillation, ion-exchange treatment, reverse osmosis or any other suitable process; contains no added substance; and NOT used in preparations intended for parenteral administration

Purified Water

Which kind of water is purified by distillation or by reverse osmosis; contains no added substances, and intended for use as a solvent for the preparation of parenteral solutions?

Water for Injection

Match the following oral preparation to its corresponding definition

A. Linctus

B. Elixir

C. Oral emulsion

D. Oral drop

E. Syrup

F. Oral solution

An oral liquid that contains one or more active ingredients that are unstable in the water phase and is stabilized in oil-in-water dispersions. Either or both phases may contain dissolved solids

C

Match the following oral preparation to its corresponding definition

A. Linctus

B. Elixir

C. Oral emulsion

D. Oral drop

E. Syrup

F. Oral solution

An oral liquid that is prepared to be administered in small quantities with the help of a suitable measuring device

D

Match the following oral preparation to its corresponding definition

A. Linctus

B. Elixir

C. Oral emulsion

D. Oral drop

E. Syrup

F. Oral solution

A viscous oral liquid that contains one or more active ingredients dissolved in a suitable base that generally contains a higher concentration of sugar or other sugars

A

Match the following oral preparation to its corresponding definition

A. Linctus

B. Elixir

C. Oral emulsion

D. Oral drop

E. Syrup

F. Oral solution

A clear flavored oral liquid containing one or more active ingredients dissolved in a suitable base that contains a high proportion of sucrose and may also contain ethanol (95%) or a diluted ethanol

B

Match the following oral preparation to its corresponding definition

A. Linctus

B. Elixir

C. Oral emulsion

D. Oral drop

E. Syrup

F. Oral solution

An oral liquid that contains one or more active ingredients that are dissolved in a suitable base

F

Select the correct statement about oral solutions

Oral pharmaceutical solutions are usually formulated so that the patient receives the usual dose in a conveniently administered volume, such as 5 ml (1tsp), 10 ml, or 15 ml (1tbsp)

Determine which undesirable characteristic of a dispersed phase of a suspension.

Enhances crystal growth formation

Identify the undesirable quality of a suspension.

Suspended particles settle rapidly

Which of the following is a disadvantage characteristic of a deflocculated suspension?

Formation of a compact when the particles eventually settle

Disadvantage of a highly viscous suspension

Not poured out easily

Identify the pharmaceutical dispersed system that is a low-viscosity liquid preparation intended for application to the skin.

Lotion

Which of the following statements describes an aerosol?

Pressurized dosage forms that contain one or more active ingredients, which upon activation emit a fine dispersion of liquid and/or solid materials in a gaseous medium

Dosage form that is dependent on the function of its container

Aerosol

SPF stands for

Sun protection factor

Pectin

Organic hydrogel

Identify the concentration of sodium in a TPN preparation

100-120 mEq

Identify the use of the IV fluid, 5% Dextrose inj.

I. Correction of disturbances in electrolytes

II. Correction of disturbances in body fluids

III. Means of providing nutrition

IV. Vehicle

II and III

Identify the use of the IV fluid: Ringer's injection

I. Correction of disturbances in electrolytes

II. Correction of disturbances in body fluids

III. Means of providing nutrition

IV. Vehicle

I and II

Identify the use of the IV fluid: Amino acid injection

I. Correction of disturbances in electrolytes

II. Correction of disturbances in body fluids

III. Means of providing nutrition

IV. Vehicle

II and III

Identify the use of the IV fluid: Sodium lactate injection

I. Correction of disturbances in electrolytes

II. Correction of disturbances in body fluids

III. Means of providing nutrition

IV. Vehicle

I and II

Identify the use of the IV fluid: Invert sugar injection

I. Correction of disturbances in electrolytes

II. Correction of disturbances in body fluids

III. Means of providing nutrition

IV. Vehicle

II and III

Select the correct statement

I. Diluting agents for injections may be aqueous or nonaqueous

II. Aqueous diluting agents include such preparation as Sterile water for injection, Propylene Glycol and Dextrose

III. Nonaqueous diluting agents are generally fatty oils of vegetable origin and fatty esters and polyols

IV. Nonaqueous diluting agents are used to dissolve or dilute water-soluble substance

V. Aqueous diluting agents are used to suspend water-soluble substances when it is desired to decreases the rate of absorption and prolong the duration of action of the drug substances.

I, III