Gross Path Challenges

#17, 18, 19, 19 (again)

Kitten. MDX and likely cause

Cyclopia

Synophthalmis

Defect in the Sonic Hedgehog gene

Snake. MDX and cause.

MF/C necrotizing stomatitis; “mouth rot”

Gram-negative bacteria

Pseudomonas aeruginosa or Aeromonas hydrophila

Rat. MDX.

Mammary fibroadenoma

Benign

Mouse; usually malignant and d/t mouse retroviruses

Rabbit. MDX and cause.

Diffuse severe fibrinosuppurative peritonitis

Pasteurella multocida; “snuffles”

One other is S. aureus, but PM is better

Ox. MDX and 3 possible causes.

Diffuse hepatocellular necrosis and loss with fibrosis (cirrhosis)

1. Senecio spp.

2. Crotalaria spp.

3. Pithomyces chartarum

4. Aflatoxin

5. Pyrrolizidine alkalyoid

   Another organ? Skin; photosensitization

Rat. MDX.

Zymbal's Gland Tumor

Usually benign; but they’re ugly

Dog. 2 MDX.

1. Persistent right aortic arch; vascular ring anomaly

2. Proximal esophageal dilation; megaesophagus

Sheep. MDX and 2x causes.

Multifocal/coalescing ulcerative stomatitis

Causes: Ovine Orbivirus; Ovine movbillivirus (Peste des petits ruminants)

Goat. MDX, cause, and name 2 other possible lesions.

Diffuse lymphocytic interstitial pneumonia

SRLV; CAEV

Encephalitis, arthritis, mastitis

Horse. MDX and a cause.

Massive hepatocellular necrosis.

Equine parvovirus

Ox. MDX

Valvular hematocyst

Common incidental findings; blood —> serous later when blood is absorbed

Otter. MDX and Cause

Diffuse necrotizing mesenteric and subcutaneous steatitis

All fish diet leading to vitamin E deficiency

Also seen in herons

Dolphin. MDX and cause.

MF/C granulomatous dermatitis

Lacazia loboi

Fungal disease

Piglet. MDX and cause.

MF/C proliferative and necrotizing dermatitis (pock)

Swine poxvirus

Goldfish. Name the condition.

Polycystic kidney disease

DDX: hepatocellular tumor

Turtle. Pathogenesis.

Vitamin A deficiency —> squamous metaplasia of the lacrimal glands —> duct obstruction —> edema ± secondary bacterial infection

Lamb. MDX and 2 possible causes.

Multifocal necrotizing hepatitis

Causes: Campylobacter fetus subspecies fetus and Flexispira rappini

Cat. MDX

Meningioma

Dog. Cause.

Inactive of the gene myostatin

Goat. MDX.

Make pseudohermaphrodite

Cat. MDX and cause.

MDX: Subpleural mineralization of the intercostal muscles

Cause: Chronic renal failure; uremia

Calf. MDX.

MF necrotic abomasitis with ulcers

*Ulcers in neonates can be caused by stress

Woodchuck. MDX and cause.

Hepatocellular carcinoma

Hepadnavirus

Cat. MDX and cause.

MF mineralization of the mesenteric arteries

Cause: renal failure; uremia

Goat. MDX and a cause.

Diffuse, chronic, lymphocytic synovitis

Causes:

1. Mycoplasma capricolum; also causes contagious caprine pleuropneumonia

2. G- bacterium

3. CAEV (older animals > young animals)

Dog. MDX and cause.

Bilateral, diffuse, corneal edema

Type III hypersensitivity following vaccination or infection with type I canine Adenovirus; damage to the endothelium

Old vaccines were modified live

Chicken. MDX and 3 possible causes.

Multifocal hepatocellular lymphoma

1. Gallid herpesvirus 2 (T cells; mareks)

2. Avian retrovirus (leukosis virus; avian leukosis; B cells)

3. Avian reticuloendothelial virus (either cell)

Ferret. MDX.

Thymic lymphoma

Juvenile: tends to affect the viscera (thymus, liver, spleen)

Rabbit. Cause.

MF/C proliferative and lymphoplasmacytic cholangitis

Cause: Eimeria stiedae; lives in the epithelium of the the bile ducts

Cat. MDX

Intestinal carcinoma

Carcinomatosis

Stricture of the small intestine

Cow. MDX and 3 possible causes.

MF/C proliferative and necrotizing mammalitis (pock)

1. Bovine orthopoxvirus (cowpox)

2. Bovine parapox (papular stomatitis)

3. Bovine herpesvirus-2 (mammalitis)

4. Maybe FMD or vesicular stomatitis

Ox. MDX and a cause.

MF/C necrotizing stomatitis, palatitis, and chealitis

Bovine pestivirus

Bovine herpesvirus-2

Bluetongue

Rinderpest

Horse. MDX and a cause.

Diffuse fibrinonecrotic enteritis

Salmonella typhimurium

Chicken. MDX.

Diffuse granulomatous pericarditis and epicarditis with urates

Caused by dehydration

Rat. MDX.

Endometrial stromal polyp

Quail. MDX and cause

MF/C necrotizing typhlitis, enteritis, and cholitis

Clostridium colinum

“Quail disease”

Dog. MDX and name the condition.

MF/C suppurative metaphyseal osteomyelitis with infraction

Metaphyseal osteopathy

Young dogs, previous inflammatory disease; disruption of neutrophils

Calf. MDX and two possible causes.

Unilateral fibrinonecrotic laryngitis

Fusobacterium necrophorum

Histophilus somni

“Necrotic laryngitis”

Duck. MDX and a cause.

Rice breast

MDX: Multiple skeletal muscle sarcocysts

Sarcosystis rileyi

Dog. MDX.

Vertebral myeloma

Clinicopathologic abnormalities:

Hypergamaglobulinemia

Bence Jones proteins in urine