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Two broad categories of antepartum fetal surveillance tools
Biophysical assessment, which uses fetal biophysical activity or imaging, and biochemical assessment, which uses lab analysis of maternal blood or fetal tissue and fluid
Examples of biophysical assessment tools
Daily fetal movement count, ultrasonography, Doppler blood flow analysis, biophysical profile, and the nonstress test and contraction stress test
Examples of biochemical assessment tools
Amniocentesis, chorionic villus sampling, percutaneous umbilical blood sampling, and maternal assays such as alpha-fetoprotein and cell-free DNA screening
Daily fetal movement count methods
Once a day for 60 minutes, or 2 to 3 times daily after meals for 2 hours each
Reassuring daily fetal movement count
10 movements within a 12-hour period
Biophysical profile (BPP)
A test combining 5 components, 4 ultrasound observations plus the nonstress test, to assess fetal well-being, with each component scored 2 or 0
The 5 components of the biophysical profile
Fetal breathing movements, gross body movement, fetal tone, reactive fetal heart rate on the NST, and qualitative amniotic fluid volume
Normal finding for fetal breathing movements on a BPP
1 or more episodes of rhythmic breathing lasting 30 seconds or more within 30 minutes
Normal finding for gross body movement on a BPP
3 or more discrete body or limb movements within 30 minutes
Normal finding for amniotic fluid volume on a BPP
1 pocket of fluid measuring at least 2 cm in vertical axis
BPP score indicating a reassuring result
8 to 10 with normal fluid, indicating low risk of chronic fetal asphyxia
BPP score indicating strong suspicion of chronic fetal asphyxia
4 or less, requiring further evaluation and likely birth
Modified biophysical profile
Combines the nonstress test with the amniotic fluid index only
A fetus scores 2 on breathing movements, 2 on body movement, 0 on tone, 2 on the NST, and 0 on amniotic fluid volume. What is the total BPP score and what does it suggest
A score of 6, which is equivocal and suggests chronic fetal asphyxia should be suspected, usually prompting repeat testing within 24 hours
Nonstress test (NST) theory
A healthy fetus with an intact autonomic nervous system will show acceleration of the fetal heart rate with fetal movement
Reactive NST
2 or more FHR accelerations peaking at 15 beats per minute or more above baseline, each lasting 15 seconds or more, within a 20-minute window
Nonreactive NST
Fails to meet reactive criteria after 40 minutes of monitoring
Purpose of vibroacoustic stimulation during an NST
To wake a sleeping fetus or elicit an FHR response if the tracing is nonreactive
Contraction stress test (CST) purpose
Evaluates the respiratory function of the placenta by observing the fetal heart rate response to uterine contractions, giving an earlier warning of fetal compromise than the NST
How contractions are stimulated for a CST
Nipple stimulation or IV oxytocin, until 3 contractions lasting 40 seconds or more occur within a 10-minute window
Negative CST result
No late decelerations with any contraction, a normal result
Positive CST result
Late decelerations follow 50 percent or more of contractions, an abnormal result
A patient undergoing a CST has late decelerations after more than half of her contractions. How should the nurse document this result
As a positive CST, indicating an abnormal result
Ultrasound uses relevant to a diabetic pregnancy
Confirming gestational age, serial assessment of fetal growth to detect macrosomia, evaluating fetal anatomy for congenital anomalies, and assessing amniotic fluid volume for hydramnios
Why serial ultrasounds are important in gestational diabetes
To monitor for macrosomia and hydramnios, both recognized complications of diabetes in pregnancy
Normal physiologic dyspnea of pregnancy
Caused by progesterone increasing tidal volume and sensitizing the respiratory center to carbon dioxide, occurring with mild exertion or at rest without other signs of distress
Pathologic causes of dyspnea in pregnancy that must be ruled out
Cardiac disease, pulmonary embolism, asthma exacerbation, severe anemia, pulmonary edema, and amniotic fluid embolism
Most common symptom of heart disease in pregnancy
Dyspnea on exertion
A pregnant patient reports mild shortness of breath at rest in her third trimester with normal vital signs. How should the nurse interpret this
As likely normal physiologic dyspnea of pregnancy, since it occurs without other signs of distress
A pregnant patient reports sudden dyspnea with chest pain and tachycardia. What should the nurse suspect
A pathologic cause such as pulmonary embolism, requiring urgent evaluation rather than being dismissed as normal pregnancy dyspnea
Two-step screening approach for gestational diabetes
A 1-hour 50-g oral glucose tolerance test with no fasting required, followed by a 3-hour 100-g OGTT for diagnosis if the first test is elevated
One-step screening approach for gestational diabetes
A 2-hour 75-g OGTT after an overnight fast, with diagnosis made if any one value is met or exceeded
Target fasting blood glucose in pregnancy
95 mg per dL or less
Target 1-hour postprandial blood glucose in pregnancy
140 mg per dL or less
Target 2-hour postprandial blood glucose in pregnancy
120 mg per dL or less
First-line treatment for gestational diabetes
Medical nutrition therapy and exercise
Traditional first-line medication for gestational diabetes when diet and exercise are insufficient
Insulin, since it does not cross the placenta
Postpartum follow-up recommended after a diagnosis of gestational diabetes
A 2-hour 75-g OGTT at 6 to 12 weeks postpartum, since these women carry an increased lifelong risk for type 2 diabetes
Classic neonatal finding in an infant of a diabetic mother
Macrosomia, caused by fetal hyperinsulinemia in response to chronically elevated maternal glucose crossing the placenta
Why does an infant of a diabetic mother develop hypoglycemia after birth
The newborn continues producing high insulin levels after the maternal glucose supply is cut off at birth
Priority nursing interventions for a newborn of a diabetic mother
Early and frequent carbohydrate feedings, serum glucose monitoring, and adequate thermoregulation
A newborn of a diabetic mother appears large with a round, full face and becomes jittery 2 hours after birth. What should the nurse suspect and do
Neonatal hypoglycemia, and the nurse should check blood glucose promptly and initiate early feeding
Most common cause of hyperthyroidism in pregnancy
Graves' disease
Hyperthyroidism symptoms in pregnancy
Weight loss, heart rate over 100, goiter, heat intolerance, and nervousness
Hypothyroidism symptoms in pregnancy
Weight gain, lethargy, decreased exercise capacity, and cold intolerance
Preferred antithyroid medication in the first trimester for hyperthyroidism
Propylthiouracil (PTU)
Treatment for hypothyroidism in pregnancy
Thyroid hormone supplementation with levothyroxine, with the dose often needing to increase during pregnancy
Thyroid storm
A life-threatening exacerbation of uncontrolled hyperthyroidism with high fever, severe tachycardia, and heart failure
Why pregnancy increases risk of sickle cell crisis
The increased metabolic demands, physiologic hemodilution, and hypercoagulable state of pregnancy
Maternal risks of sickle cell anemia in pregnancy
Increased risk for preeclampsia, infection, pulmonary complications such as acute chest syndrome, and painful vaso-occlusive crises
Fetal risks of sickle cell anemia in pregnancy
Intrauterine growth restriction, preterm birth, and increased perinatal mortality from chronic placental hypoxia
Why folic acid supplementation is important in sickle cell anemia
Increased red blood cell turnover increases folate needs
Systemic lupus erythematosus (SLE) in pregnancy
An autoimmune disease that can flare during pregnancy, most commonly in the first and second trimester and the immediate postpartum period
Pregnancy risks associated with active lupus nephritis or antiphospholipid antibodies
Higher risk for preeclampsia, intrauterine growth restriction, and pregnancy loss
Most serious manifestation of neonatal lupus
Congenital heart block, caused by transplacental passage of maternal antibodies
Tobacco use effects in pregnancy
Ectopic pregnancy, placenta previa, placental abruption, preterm PROM, orofacial clefts, IUGR, low birth weight, and increased perinatal mortality
Safe amount of alcohol during pregnancy
No safe amount at any time in pregnancy
Most commonly used illicit drug in pregnancy
Marijuana
Cocaine and methamphetamine effects in pregnancy
Increased preterm labor, placental abruption, preeclampsia, IUGR, and low birth weight from vasoconstrictive effects
Why universal screening for substance use is recommended in pregnancy
All pregnant women should be screened regardless of age, race, or socioeconomic status, since risk cannot be reliably predicted by demographics alone
Barriers to substance abuse treatment in pregnancy
Social stigma, fear of losing custody or criminal prosecution, and treatment programs that don't address issues specific to pregnant women
Gestational hypertension
Blood pressure 140 over 90 mm Hg or higher on 2 occasions at least 4 hours apart, after 20 weeks gestation, without proteinuria or other signs of preeclampsia
Preeclampsia definition
Gestational hypertension plus proteinuria, or hypertension with evidence of other end-organ dysfunction even without proteinuria
Eclampsia
Seizure activity or coma in a woman with preeclampsia, with no other cause for the seizure
Chronic hypertension in pregnancy
Hypertension present before pregnancy or diagnosed before 20 weeks gestation, persisting after birth, without proteinuria
Chronic hypertension with superimposed preeclampsia
A sudden increase in previously controlled blood pressure or new onset proteinuria in a woman with chronic hypertension
Strongest risk factors for preeclampsia
Multifetal pregnancy, chronic hypertension, history of preeclampsia in a previous pregnancy, and pregestational diabetes
Fetal risk from hypertensive disorders in pregnancy
Reduced placental perfusion causing IUGR, oligohydramnios, preterm birth, and placental abruption
Blood pressure criteria for preeclampsia diagnosis
Systolic 140 mm Hg or higher, or diastolic 90 mm Hg or higher, on 2 occasions at least 4 hours apart, after 20 weeks gestation
Proteinuria criteria for preeclampsia diagnosis
300 mg or more in a 24-hour urine collection, or a protein to creatinine ratio of 0.3 or higher
Blood pressure defining preeclampsia with severe features
Systolic 160 mm Hg or higher, or diastolic 110 mm Hg or higher, on 2 occasions at least 4 hours apart
Laboratory findings that define preeclampsia with severe features
Thrombocytopenia below 100,000 per microliter, impaired liver function, and renal insufficiency with creatinine above 1.1 mg per dL
Symptoms that define preeclampsia with severe features
New onset headache unresponsive to medication, visual disturbances, and pulmonary edema
Underlying pathophysiology of preeclampsia
Disruptions in placental perfusion and endothelial cell dysfunction leading to generalized vasospasm
Deep tendon reflex findings concerning for worsening preeclampsia
Hyperreflexia and clonus
Immediate priority during an eclamptic seizure
Maintaining a patent airway and patient safety
Treatment goal for gestational hypertension or preeclampsia without severe features
Deliver as close to term as possible, around 37 weeks, with outpatient monitoring including twice-weekly BP checks and fetal surveillance
Is strict bed rest currently recommended for hypertensive disorders of pregnancy
No, activity restriction is no longer recommended since no evidence supports benefit
Prevention strategy for preeclampsia in high-risk women
Low-dose aspirin therapy
Magnesium sulfate loading dose for preeclampsia seizure prophylaxis
4 to 6 g IV over 20 to 30 minutes
Magnesium sulfate maintenance dose
1 to 4 g per hour
Therapeutic magnesium level for seizure prophylaxis
4 to 7.5 mEq per L, or 5 to 8 mg per dL
Signs of magnesium sulfate toxicity
Respiratory rate fewer than 12 breaths per minute, absent deep tendon reflexes, urine output less than 25 to 30 mL per hour, and altered level of consciousness
Antidote for magnesium sulfate toxicity
Calcium gluconate
Contraindications to magnesium sulfate
Myasthenia gravis, hypocalcemia, and renal failure
Maximum total IV intake while on magnesium sulfate
125 mL per hour
A patient on magnesium sulfate has a respiratory rate of 10 and absent deep tendon reflexes. What should the nurse do first
Stop the magnesium sulfate infusion immediately and prepare to administer calcium gluconate
General principle for interpreting the color of vaginal bleeding
Dark red blood is typically venous in origin while bright red blood is typically arterial in origin
Color of bleeding in placental abruption
Dark red
Color of bleeding in placenta previa
Bright red
Pain characteristic of placental abruption
Present, ranging from mild to agonizing unremitting uterine pain
Pain characteristic of placenta previa
Absent
Uterine tone in placental abruption versus placenta previa
Increased and possibly tetanic in abruption, versus normal and relaxed in previa
Why a vaginal exam should never be performed on a woman with active third-trimester bleeding until previa is ruled out
A digital exam can provoke severe hemorrhage if placenta previa is present
Hyperemesis gravidarum
Excessive vomiting in pregnancy accompanied by dehydration, electrolyte imbalance, ketosis, and acetonuria, distinct from normal morning sickness
Risk factors for hyperemesis gravidarum
History of hyperemesis in a prior pregnancy, carrying a female fetus, and multifetal gestation
Why thiamine is given before dextrose in severe hyperemesis gravidarum
To prevent Wernicke encephalopathy
HELLP syndrome
Hemolysis, Elevated Liver enzymes, and Low Platelets, a laboratory diagnosis representing a severe complication of preeclampsia
Risks associated with HELLP syndrome
Pulmonary edema, acute renal failure, disseminated intravascular coagulation, placental abruption, liver hemorrhage, and stroke
Macrosomia definition
Estimated fetal weight greater than 4000 to 4500 g, or greater than the 90th percentile for gestational age