Studied by 3 people
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skin mechanoreceptors that feel and respond to skin stretching
Ruffini end organs
where does the Ruffini end organ transmit the stretch signal? why?
to the tendon, in order to cause a lengthening of the collagen fibers
cells that produce proteins in the tendon
fibroblasts
what links collagen fibers in the ECM to the cytoskeleton?
integrins
junctions that attach adjacent cells and allow for transfer of info
desmosomes, adhesions, gap junctions
transfer of signal from the skin down to the tendon cell level
mechanotransduction
what are the steps of mechanotransduction?
mechanical stimulus, tissue forces, cellular forces, molecular response
what is the force typically responded to in tendon tissues?
tension
proteins that span the cell membrane
integrins
how is a signal transduced from the membrane to the nucleus
direct physical connection or signaling cascades
what theory is mechanotransduction in the tendon and example of?
physical stress theory
what is physical stress?
force applies to an area of tissue
what defines the boundaries for effective doses of physical stress?
thresholds
what is necessary in order to cause adaption?
overload
do thresholds stay constant over time?
no, they change and dose must change accordingly
what does inflammation do to the set point oof thresholds?
decreases
new acronym for care of inflamed tissue
POLICE (protection, optimal loading, ice, compression, elevation)
key question as a PT
am I delivering the correct dose to produce the desired tissue response?
