Mechanobiology and Physical Stress Theory

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18 Terms

1

skin mechanoreceptors that feel and respond to skin stretching

Ruffini end organs

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2

where does the Ruffini end organ transmit the stretch signal? why?

to the tendon, in order to cause a lengthening of the collagen fibers

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3

cells that produce proteins in the tendon

fibroblasts

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4

what links collagen fibers in the ECM to the cytoskeleton?

integrins

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5

junctions that attach adjacent cells and allow for transfer of info

desmosomes, adhesions, gap junctions

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6

transfer of signal from the skin down to the tendon cell level

mechanotransduction

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7

what are the steps of mechanotransduction?

mechanical stimulus, tissue forces, cellular forces, molecular response

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8

what is the force typically responded to in tendon tissues?

tension

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9

proteins that span the cell membrane

integrins

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10

how is a signal transduced from the membrane to the nucleus

direct physical connection or signaling cascades

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11

what theory is mechanotransduction in the tendon and example of?

physical stress theory

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12

what is physical stress?

force applies to an area of tissue

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13

what defines the boundaries for effective doses of physical stress?

thresholds

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14

what is necessary in order to cause adaption?

overload

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15

do thresholds stay constant over time?

no, they change and dose must change accordingly

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16

what does inflammation do to the set point oof thresholds?

decreases

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17

new acronym for care of inflamed tissue

POLICE (protection, optimal loading, ice, compression, elevation)

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18

key question as a PT

am I delivering the correct dose to produce the desired tissue response?

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