chapter 19 - bone marrow failure

fatigue, infection, bleeding

clinical consequences of pancytopenia include:

unknown cause

idiopathic acquired aplastic anemia is due to:

destruction of stem cells by autoimmune T cells

pathophysiologic mechanism in acquired idiosyncratic aplastic anemia is:

very severe

what is the aplastic anemia classification of a 15-year-old with

• bone marrow cellularity — 10%

• Hgb — 7 g/dL

• absolute neutrophil count — 0.1 × 10⁹/L

• platelet count — 10 × 10⁹/L

macrocytosis, thrombocytopenia, neutropenia

most consistent peripheral blood findings in severe aplastic anemia

bone marrow transplant with an HLA-identical sibling

treatment that has shown best success rate in young px with severe aplastic anemia

diepoxybutane-induced chromosome breakage

test that is most useful in differentiating Fanconi anemia from other other causes of pancytopenia

premature death of hematopoietic growth factors

in dyskeratosis congenita, mutations in genes that code for the telomerase complex may induce bone marrow failure by causing which?

only erythropoiesis is affected

diamond-blackfan anemia differs from Fanconi anemia in that the former:

congenital dyserythropoietic anemia

anemia that should be suspected in a patient with refractory anemia, reticulocytopenia, hemosiderosis, and binucleated erythrocyte precursors in the bone marrow

inadequate production of erythropoietin

primary pathophysiologic mechanism of anemia associated with chronic kidney disease:

reticulocytosis

findings not consistent with myelophthisic anemia