Cornavirdidae: SARS, MERS, Covid-19

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8 Terms

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PL

papain-like protease, cause polyprotein cleavage, 

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3CL

3C-like cystiene protease, cause polyprotein cleavage

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PP1ab

protein phosphatase 1, larger fusion protein produces by ribosome frameshift 

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Nsp14

3 motifs conserved in DNA exonucleases, proof reads viral RNA 

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ACE2

angiotensin converting enzyme 2, main entry receptor of SARS-Cov2

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CEACAM

carcinoembryonic antigen-related cell adhesion molecule, type of cell surface protein

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HR

heptad repeat, repeating AA sequence found in spike protein essential for membrane fusion 

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Katalin kariko and Drew weissman

nobel prize for discoveries concerning base modification that allowed for the effective mRNA vaccine for covid