Ch 7 Complement System

proteins of the complement system are part of

innate immunity

characteristic of complement

plays a role in the lysis of target cells coated with specific antibodies

complement is essential for our body’s response to infection by bein heavily involved in

inflammation

which complement component is found in both classical and alternative pathways

C3

which can activate the alternative complement pathway

C3b

what is the correct order of activation of complement in the lectin activation

MBL, C4, C2, C3

the lectin pathway is initiated by the presence of

Mannose

The recognition unit in the classical complement pathway consists of

C4b2a3b

Which immunoglobulin can activate complement

IgM

what functions by inserting itself into target membranes and forming channels or holes in the membranes

C5b6789

C5 convertase of the alternative pathway of complement activation is

C3bBb3bP

C5b6789 function is

target cell lysis

what acts as an opsonin

C3b

which complement protein is the key intermediate in all complement pathways

C3

which complement components has chemotactic activity

C3a

the alternative and classical pathway C3 convertases are destabilized as a means of downregulating complement function. One molecule that performs this function is

membrane cofactor protein

formation of the membrane attack complex (C5-C9) is stopped by which factor

S protein

which factor must be associated with factor H to inactivate complement components

Factor 1

Lack of complement components C5 through C9 may result in what condition

Neisseria infection

Dense deposits of C3 breakdown products can accumulate in the kidneys because of

autoantibodies that bind C3bBb

lack of the complement inhibitor C11NK results in what disease

Hereditary Angioedema

Kidney glomeruli can become obstructed with immune complexes as a result of

inadequate C3b-mediated opsonization

what complement therapeutics targets the classical pathway

C1-INH

antibodies targeting C1’s as therapy for cold agglutinin autoimmune hemolytic anemia would cause

high CH50

what reagent is present in a CH50 assay and absent in AH50 assay

red blood cells

decreased Ch50 and a decreased AH50 would indicate a low amount of which complement components

C3

test that could be used to determine whether a patient has a specific deficiency in C3

radial immunodiffusion

patient has an abnormal alternative pathway activation patter. what complement proteins should be assessed to further investigate the problem

C3

a normal CH50 and low AH50 may indicate

alternative pathway deficiency issues

patients undergoing treatment with complement therapeutics for hereditary angioedema (HAE) would expect to ahve what laboratory values

increased C4 and C2

therapeutics targeting the alternative pathways typically cause

decreased AH50