hatcher content part 1

what is supramolecular chemistry?

science of the association between molecules and/or ions induced by non-covalent bonding interactions displaying a molecular recognition event

what ways can we generate complex structures?

build from the bottom up or remove material from a larger structure

what is self assembly?

spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by non-covslent bonds e.g. hydrogen bonds or metal coordination bonds

self assembled structures represent thermodynamic minima

in kineticslly and thermodynamically controlled reactions, what controls the product?

kinetic control - relative magnitude of the transition states determines product distribution

thermodynamic control - relative thermodynamic stabilities of the products are responsible for the product ratio

how can you control selectivity in self assembly?

intermolecular forces exist between the components that control orientation, leading to reversible assembly of a super molecule

molecular building blocks must be designed or encoded to be able to recognise each other (complementarity)

come together in a predesigned manner and self organise

what notation is used to measure hydrogen bonding motifs?

D = discrete/finite

R = ring

C = chain

S = intramolecular

G^a subscript d (n)

G = pattern designators above

a = no. H bond acceptors

d = no. H bond donors

n = no. atoms in the motif

give some examples of using the hydrogen bond notation

for one single hydrogen bond, n = 2

for a cyclic motif made of two carboxylic acid groups that are part of a larger molecule, n = 8

you dont include the atoms outside of the ring

what is a template?

a structure that guides the formation of a determined shape from other materials

what are the benefits of using templates?

templates direct chemical structure formation, favouring the synt.hesis of a given product, and improving selectivity

make feasible the preparation of chemical objects that would otherwise be impractical