serotonin hehe

5-HT1D / 1B

Brain - mediate synaptic inhibition via K conductance

DOC FOR MIGRAINE ANG AGONIST

Gi

5-HT2

Brain - increase in appetite

Smooth muscles - contractions (uterus, gut, bronchi)

Relaxation (vessel)

Gq

5-HT3

Area postrema - vomiting and nausea

Sensory and enteric nerves

Antagonists are antiemetic

NA/K (ligand-gated)

5-HT4

presynaptic nerve terminals in ENS

GIT - motility

Gs

TXA2

Potent vasoconstrictor and smooth muscle mitogen

PGF2a

Vasoconstrictor but not a smooth muscle mitogen

PGI2 and PGE2

Vasodilators

PGE2 ANG PGF2a

Contracts longitudinal muscle

PGF2a ang PGI2

weakly contracts circular muscle

PGE2 and PGI2

Relaxes respiratory smooth muscle

PGD2

TXA2

PGF2a

Contracts respiratory muscle

Cysteinyl leukotrienes

LTC4

LTD4

LTE4

Bronchoconstrictors and stimulates secretion and edema

PGI2

Product of COX2

Potent platelet inhibitor

If COX2 is inhibited

• increased platelet aggregation and activation

TXA2

Product of COX1

Powerful platelet aggregation inducer

Irreversibly inhibited by chronic administration of aspirin at lower doses

If COX2 is inhibited, it increases the platelet aggregation

• when combined with TXA2 it increases platelet aggregation so much that it can lead to prothrombotic effect which is a stroke or MI

PGE2

PGI2

Maintain renal blood flow

vasodilating

TXA2

causes intrarenal vasoconstriction

PGF2a

TXA2

PGE2 (low)

uterine contraction

PGI2

PGE2

Uterine relaxation

PGI2

enhances erection

relaxation

PGE2

increases body temperature

PGE2

PGI2

associated with inflammation

PGD2

chemoattractant

mast cells

chemotaxis and migration of th2 lymphocytes

PGE2

increases bone turnover

PGE

PGF

PGD

lowers intraocular pressure

LTB4

chemoattractant for t lymophocytes, neutrophils, eosinophils, monocytes, mast cells

cysteinyl leukotrienes

chemoattractant for eosinophils, t lymphocyte

LTC4

LTD4

reduces myocardial contractility and coronary blood flow

LTB4

chemoattractant for neutrophils

for those with inflammatory bowel disease

LTC4

LTD4

potent bronchoconstrictors

Zileuton

blocks 5-LOX

Zafirlukast

Montelukast

Panlukast

selective antagonist ro CysLT1

Misoprostol

Gemeprost

PGE1

Increase mucus and bicarb

abortifacient

peptic ulcer disease

can cause miscarriage

teratogenic

• facial deformities (moebius sequence)

Asprostadil

PGE1

vascular relaxation and vasodilation

for erectile dysfunction

for patent ductus arteriosus

can cause priapism

• abnormal erection, long lasting hehehehe

Dinoprostone

PGE2

Uterine and cervical smooth muscle relaxation and vasodilation

for cervical ripening (labor)

can cause fetal trauma

Carboprost

PGF2a

control of postpartum hemorrhage

transient vasoconstriction

Latanoprost

PGF2a

for glaucoma

alters iris color

Corticosteroids

inhibits phospholipase A2

for addisons