H220 Week #3 (why do our bodies grow old?)
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31 Terms
Compression of Morbidity
Healthy old age, rapid decline and death
Normal Aging
aging is a time dependent biological process
Senescence
biological process of growing old or a state where cells permanently stop dividing while remaining metabolically active
Gompertz Law
death rate doubles every 8 years
Comparative anatomy
Studying species, rate correlated with time till death rate doubles
Rate of living
metabolism and life expectancy are interelated
Chance
result of external events
4 theories of chance
wear and tear, somatic mutation, error accummulation/catastrophe, waste theory
somatic mutation
radiation mutate/experience genetic change
error accummulation/catastrophe
random changes to genetic code that makes it unreadable
waste theory
cell waste accummulates and interferes with metabolism
fate
result of internal necessity (cell —> aging process), genetic
5 theories in regards to fate
autoimmune theory
aging clock
cross linkage theory
free radical theory
cellular theory
Autoimmune theory
immune system attacks itself
Aging clock
programmed aging
example of aging clock
menopause
cross linkage theory
bodily changes are due to accumulation of collagen
free radical theory
accumulation of free radicals
what neutralizes free radicals
anti oxidants
cellular theory
overtime, aging results from progressive weakening of cell division capacity
Leonary Hayflick
cells have fixed lifespan, cell replication decreases as age increases
Hayflick limit
number of cell divisions cells has
Compression of Morbidity (Vitality and Aging)
Fries and Crapo 1980’s
infirmity
illness
Compression of Morbidity - Fries and Crapo
human life span fixed
age at first infirmity will increase
duration of infirmity will decrease
Compression of Morbidity Hypothesis
Vincent Mor 2005
What would reverse effect on increase healthcare and lifestyle according to compression of morbidity
obesity
We will be able to live to 1000
Aubrey de Grey 1963
Aubrey de Grey
want to prevent/cure aging
Dont Fall for the Cult of Immortality
Olshansky
Dont Fall for the Cult of Immortality - Olshansky
Doesn’t believe in a cure to aging