Drug Quiz #3 - Antidepressant & Smoking Cessation

Amitriptyline (Brand Name)

Elavil

Amitriptyline (Therapeutic Class)

Antidepressant

Amitriptyline (Drug Class, Indication, Controlled Substance Schedule #)

Tricyclic Antidepressant; Depression; N/A

Amitriptyline (MOA)

blocks presynaptic reuptake of serotonin and norepinephrine with subsequent downregulation of adrenergic receptors

Amitriptyline (Side Effects)

Sedation, tachycardia, dry mouth, blurry vision, constipation, weight gain, confusion

Bupropion (Brand Name)

Wellbutrin (SR,XL), Zyban

Bupropion (Therapeutic Class)

Antidepressant/Smoking Cessation

Bupropion (Drug Class, Indication, Controlled Substance Schedule #)

Dopamine/Norepinephrine-Reuptake Inhibitor; Depression, Smoking Cessation Assistance; N/A

Bupropion (MOA)

Weakly inhibits norepinephrine and dopamine reuptake with no direct effect on serotonin receptors or MAO

Bupropion (Side Effects)

Agitation, dizziness, constipation, tremor, insomnia, tachyarrhythmias, dry mouth

Citalopram (Brand Name)

Celexa

Citalopram (Therapeutic Class)

Antidepressant

Citalopram (Drug Class, Indication, Controlled Substance Schedule #)

Selective Serotonin Reuptake Inhibitor (SSRI); Depression; N/A

Citalopram (MOA)

Selective and potent inhibitor of presynaptic reuptake of serotonin

Citalopram (Side Effects)

Constipation, dizziness, headache, insomnia, sedation, xerostomia

Desvenlafaxine (Brand Name)

Pristiq

Desvenlafaxine (Therapeutic Class)

Antidepressant

Desvenlafaxine (Drug Class, Indication, Controlled Substance Schedule #)

Serotonin-Norepinephrine Reuptake Inhibitor (SNRI); Depression; N/A

Desvenlafaxine (MOA)

Potent reuptake inhibitor of serotonin and norepinephrine but lacks effects on muscarinic, α-adrenergic, or histamine receptors.

Desvenlafaxine (Side Effects)

Diaphoresis, dizziness, headache, nausea, dry mouth, hypertension, hyponatremia

Doxepin (Brand Name)

Sinequan, Silenor

Doxepin (Therapeutic Class)

Antidepressant

Doxepin (Drug Class, Indication, Controlled Substance Schedule #)

Tricyclic Antidepressant; Depression, anxiety, alcoholism, insomnia; N/A

Doxepin (MOA)

Increases the synaptic concentration of serotonin and norepinephrine in the central nervous system by inhibition of their reuptake by the presynaptic neuronal membrane, and antagonizes the histamine (H1) receptor.

Doxepin (Side Effects)

tachycardia, dry mouth, blurry vision, drowsiness, confusion, urinary retention

Duloxetine (Brand Name)

Cymbalta

Duloxetine (Therapeutic Class)

Antidepressant

Duloxetine (Drug Class, Indication, Controlled Substance Schedule #)

Serotonin-Norepinephrine Reuptake Inhibitor (SNRI); Anxiety, depression, diabetic peripheral neuropathy, fibromyalgia, musculoskeletal pain; N/A

Duloxetine (MOA)

Inhibit reuptake of norepinephrine and serotonin at presynaptic nerve terminals

Duloxetine (Side Effects)

Headache, nausea, dry mouth, constipation, dizziness

Escitalopram (Brand Name)

Lexapro

Escitalopram (Therapeutic Class)

Antidepressant

Escitalopram (Drug Class, Indication, Controlled Substance Schedule #)

Selective Serotonin Reuptake Inhibitor (SSRI); Depression, generalized anxiety disorder; N/A

Escitalopram (MOA)

Selective and potent inhibitor of presynaptic reuptake of serotonin

Escitalopram (Side Effects)

Headache, insomnia, ejaculation disorder, somnolence

Fluoxetine (Brand Name)

Prozac, Sarafem

Fluoxetine (Therapeutic Class)

Antidepressant

Fluoxetine (Drug Class, Indication, Controlled Substance Schedule #)

Selective Serotonin Reuptake Inhibitor (SSRI); Bipolar major depression, major depressive disorder, OCD, panic disorder, premenstrual dysphoric disorder, bulimea nervosa; N/A

Fluoxetine (MOA)

Selective and potent inhibitor of presynaptic reuptake of serotonin

Fluoxetine (Side Effects)

Headache, insomnia, ejaculation disorder, somnolence, tremor, xerostomia

Mirtazapine (Brand Name)

Remeron

Mirtazapine (Therapeutic Class)

Antidepressant

Mirtazapine (Drug Class, Indication, Controlled Substance Schedule #)

α2-Antagonist; Depression; N/A

Mirtazapine (MOA)

Antagonizes presynaptic α2-adrenergic auto- and heteroreceptors that are responsible for controlling the release of norepinephrine and serotonin (5-HT)

Mirtazapine (Side Effects)

Constipation, increased appetite, weight gain, somnolence, dry mouth, increased cholesterol

Nortriptyline (Brand Name)

Pamelor

Nortriptyline (Therapeutic Class)

Antidepressant

Nortriptyline (Drug Class, Indication, Controlled Substance Schedule #)

Tricyclic Antidepressant; Depression; N/A

Nortriptyline (MOA) 

Blocks presynaptic reuptake of serotonin and norepinephrine with subsequent downregulation of adrenergic receptors

Nortriptyline (Side Effects)

Constipation, blurred vision, confusion, dizziness, sexual dysfunction, urinary retention, weight gain, dry mouth, orthostatic hypotension

Paroxetine (Brand Name)

Paxil (CR)

Paroxetine (Therapeutic Class)

Antidepressant

Paroxetine (Drug Class, Indication, Controlled Substance Schedule #)

Selective Serotonin Reuptake Inhibitor (SSRI); Depression, generalized anxiety disorder, social anxiety disorder, OCD, panic disorder, posttraumatic stress disorder, premenstrual syndrome, vasomotor symptoms of menopause; N/A

Paroxetine (MOA)

Highly selective and potent inhibitor of serotonin reuptake

Paroxetine (Side Effects)

somnolence, asthenia, insomnia, abnormal ejaculation, constipation, headache

Sertraline (Brand Name)

Zoloft

Sertraline (Therapeutic Class)

Antidepressant

Sertraline (Drug Class, Indication, Controlled Substance Schedule #)

Selective Serotonin Reuptake Inhibitor (SSRI); Depression, OCD, panic disorder, premenstrual dysphoric disorder; N/A

Sertraline (MOA)

Inhibits reuptake of serotonin (5-HT) that indirectly results in a downregulation of β-adrenergic receptors

Sertraline (Side Effects)

Diarrhea, fatigue, headache, insomnia, disorder of ejaculation, reduced libido

Trazodone (Brand Name)

Desyrel

Trazodone (Therapeutic Class)

Antidepressant

Trazodone (Drug Class, Indication, Controlled Substance Schedule #)

Atypical Antidepressant; Major depressive disorder; N/A

Trazodone (MOA)

Not fully understood; suspected to be related to its potentiation of serotonergic activity in the CNS by inhibiting reuptake of serotonin, and also significantly blocks histamine (H1) and α1-adrenergic receptors.

Trazodone (Side Effects)

Dizziness, sedation, headache, dry mouth, constipation, hypotension, tremor

Venlafaxine (Brand Name)

Effexor (XR)

Venlafaxine (Therapeutic Class)

Antidepressant

Venlafaxine (Drug Class, Indication, Controlled Substance Schedule #)

Serotonin-Norepinephrine Reuptake Inhibitor (SNRI); Generalized anxiety disorder, depression, panic disorder, social anxiety disorder

Venlafaxine (MOA)

Potent reuptake inhibitor of serotonin and norepinephrine but lacks effects on muscarinic, α-adrenergic, or histamine receptors.

Venlafaxine (Side Effects)

Dizziness, headache, insomnia, somnolence, dry mouth , weakness, hypertension, hyponatremia, sexual dysfunction

Vilazodone (Brand Name)

Viibryd

Vilazodone (Therapeutic Class)

Antidepressant

Vilazodone (Drug Class, Indication, Controlled Substance Schedule #)

SSRI/5-HT1A Receptor Partial Agonist; Depression; N/A

Vilazodone (MOA)

Inhibits CNS neuron serotonin uptake, binding selectively with high affinity to 5-HT1A receptors and is a 5-HT1A receptor partial agonist.

Vilazodone (Side Effects)

Dizziness, headache, palpitations, dizziness, insomnia, sexual dysfunction, restlessness

Vortioxetine (Brand Name)

Trintellix

Vortioxetine (Therapeutic Class)

Antidepressant

Vortioxetine (Drug Class, Indication, Controlled Substance Schedule #)

SSRI/5-HT1aA Receptor Partial Agonist/Serotonin 5-HT3 Receptor Antagonist; Major Depressive Disorder; N/A

Vortioxetine (MOA)

Inhibits reuptake of serotonin (5HT), inhibits serotonin 5-HT3 and partial agonist of serotonergic 5-HT (1A) receptors

Vortioxetine (Side Effects)

Transient nausea, sexual disorder, diarrhea, dry mouth, pruritus, dizziness, abnormal dreams