Misoprostol - for Peptic Ulcer Disease

Practice flashcards based on the pharmacology of Misoprostol, covering its uses, side effects, administration, and precautions.

What is the therapeutic use of Misoprostol?

• Prevention of gastric ulcers from long-term NSAID use.

What are the common adverse drug reactions associated with Misoprostol?

• Miscarriage

• Dysmenorrhea, diarrhea

• Uterine cramping (increases uterine contraction)

• Spotting

• Abdominal pain
  
  “Miss. Prostol is an MD in the USA”

What should be monitored when a patient is on Misoprostol?

• Severe diarrhea, abdominal pain,

• Excessive menstrual pain, or mid-cycle bleeding.

How should Misoprostol be administered?

• Orally 4x times a day, with meals and at bedtime.

What should be confirmed before initiating Misoprostol therapy?

• Non-pregnant state, as it can cause spontaneous abortion.

What instructions should be given to clients taking Misoprostol?

• Report worsening diarrhea or abdominal pain,

• Expect diarrhea to resolve after the first week of therapy

• Drink plenty of clear fluids

• Take w/ food

• Report menstrual changes

• Avoid alcohol and irritating foods.

What are the contraindications for Misoprostol?

• Pregnancy due to teratogenic effects

• Hypersensitivity

What precautions should be taken for patients using Misoprostol?

• Caution in children younger than 18 years.

What interactions should be noted with Misoprostol?

• Antacids that contain magnesium worsen diarrhea.