PDTI final practice questions

*Asians, as compared to Caucasians, are more commonly homozygous carriers of loss-of-function alleles for

CYP2A6

Gene duplication has been identified with

CYP2D6

Which of the following statements regarding UGT1A1*28 is true?

Individuals with homozygous UGT1A1*28 genotype are at greater risk for neutropenia with irinotecan (Camptosar)

Gilberts syndrome is associated with genetic variation in which of the following UGT enzymes?

UGT1A1

Isoniazid peripheral neuropathy and hydralazine-induced lupus erythematosus are less in fast acetylators compared with slow acetylators

True

Genetic variation in which of the following enzymes is associated with decreased formation of the clopidogrel active metabolite?

CYP2C19

Metabolism of nicotine is catalyzed predominately by which of the following enzymes

CYP2A6

A person having which of the following genotypes would be classified as a CYP3A5 non-expresser?

CYP3A5 3/3

Genetic variation of which of the following enzymes is associated with decreased metabolism of efavirenz?

CYP2B6

One or more "loss-of-function" alleles have been identified with which of the following CYP enzymes?

CYP2D6

Which of the following statements are TRUE?

I. Infants have reduced skeletal-muscle blood flow.

III. Infants have slower gastric emptying time than adults.

Newborns have higher protein binding and volume of distribution, which is why they have lower peak concentration compared to adults

false

what is the usual GFR range in neonated

15-60 ml/min

A patient weight 90kg; what is the estimated body surface area?

2.06 m^2

elderly patients show prolonged gastric emptying time, more fat tissue, and decreased total body water

true

urine from patient JB has been collected for 8 hrs, and a total of 800 mg creatinine has been measured. The serum creatinine level is 0.01 mg/ml. What will be the creatinine clearance in this patient?

166 mL/min

which of the following parameter is not needed for calculating CL using the Cockfroft-Gault method?

height

According to the national kidney foundation, a GFR of 30-59 ml/min/1.73m^2 in adults indicates stage 4 of CKD (chronic kidney disease)

false

(30-59 is stage 3)

which of the following pharmacokinetic parameters would likely be different in newborns from corresponding values in adults?

A. total AUC

b. elimination and rate constant (ke)

answer- c). a and b

Aging can only impact pharmacokinetic properties of the drug (what body does to the drug) pharmacodynamic (effect of drug on body) remain unaltered.

False

which of the following weights must be used while calculating dose of an aminoglycosides for an obese patient?

adjusted body weight (ABW)

Which of the following statins would have the least variability in AUC in patients with the SLCO1B1 c.521CC genotype?

Fluvastatin

which of the following will not significantly affect P-gp function?

ABCB1*1

Which of the following do you consider when evaluating the potential effects of transporter polymorphisms on drug disposition?

a. location

b. transporter function

c, substrates

d. all of the above

select the INCORRECT statement regarding SLCO1B1

SLCO1B1 is the only gene to consider when dosing rosuvastatin

which of the following statement is true?

drug targets are typically located in tissue and organs

which of the following factors does NOT affect the pharmacokinetic/pharmacodynamic properties of a drug?

switching to a generic version of a drug

which of the following statements is/are true regarding the efficacy and safety of a drug?

pharmacokinetics and pharmacodynamics both determine the efficacy and safety

which one of the following is an example of the. most common type of genetic polymorphism that occurs approximately every 300 bp in the human genome>

a. AATCGG-> AACCGG

SNP 789 is located on Chromosome 22 and is a C/T SNP. Morgan has a C at SNP 789 on one copy of Chromosome 22. Morgan also has a C at SNP 789 on the other copy of Chromosome 22. Finally, Morgan has attached ear lobes because he is homozygous CC at SNP 789 on Chromosome 22. Using the information above, which of the following is correct?

a. Morgan has a C allele at SNP 789, a CC genotype at SNP 789, and an attached ear lobe phenotype

Which of the following statements is false?

recombination can randomly occur at any point of the human genome.

urine from patient JB has been collected for 8 hours, and a total of 800mg creatinine has been measured. The serum level is 0.01mg/ml. What will be the creatinine CL in this patient?

166 ml/min

CYP3A4 inhibitors

fluconazole

ketoconazole

itraconazole

clarithromycin

erythromycin

flagyl

CYP3A4 inducers

Rifampin, St. John's Wort

CYP2C19 1/2 translate phenotype

Intermediate Metabolizer (IM)

AMP - (Association for Molecular Pathology)

-determines which alleles to designate at Tier 1 or "must-test" alleles

-guidelines currently available for multiple genes

-CYP2C19, CYP2C9, CYP2D6, VKORC1, CYP3A4, CYPE3A5,

TPMT, NUDT15

Publishes recommendations on variations to include in testing panels

Graded as "must include" or "optional"

module 12 practice questions:::

module 12 practice questions:::