[PL 2.2] ERYTHROID PRECURSORS

What is the size range (in µm) of a Pronormoblast?

12-20µm

What erythroid precursor cell has 1 or 2 nucleoli and purple-red chromatin?

Pronormoblast

Which erythroid precursor has dark blue cytoplasm due to high RNA content?

Pronormoblast

What is the N:C ratio of a Pronormoblast?

8:1

Which erythroid precursor is capable of mitosis and produces two daughter pronormoblasts?

Pronormoblast

Where is the Pronormoblast located during erythropoiesis?

Bone marrow

What is the main cellular activity of a Pronormoblast?

Start of globin production

What is the bone marrow transit time of a Pronormoblast?

24 hours

What is the size range (in µm) of a Basophilic Normoblast?

10-15µm

Which cell has deep purple-red chromatin that begins to condense with sharp parachromatin?

Basophilic Normoblast

Which erythroid precursor has a deeper, richer blue cytoplasm?

Basophilic Normoblast

What is the N:C ratio of a Basophilic Normoblast?

6:1

Which erythroid precursor is capable of mitosis and produces two daughter cells?

Basophilic Normoblast

Where is the Basophilic Normoblast found?

Bone marrow

What is the main cellular activity of a Basophilic Normoblast?

Detectable hemoglobin synthesis

What is the bone marrow transit time of a Basophilic Normoblast?

24 hours

What is the size range (in µm) of a Polychromatic Normoblast?

10-12µm

Which erythroid precursor has condensed chromatin, no nucleoli, and murky gray-blue cytoplasm?

Polychromatic Normoblast

What is the N:C ratio progression of a Polychromatic Normoblast?

4:1 to 1:1

Which erythroid precursor is the last stage capable of mitosis?

Polychromatic Normoblast

Where is the Polychromatic Normoblast found?

Bone marrow

What is the main cellular activity of a Polychromatic Normoblast?

Increase hemoglobin synthesis

What is the bone marrow transit time of a Polychromatic Normoblast?

30 hours

What is the size range (in µm) of an Orthochromic Normoblast?

8-10µm

Which erythroid precursor has a pyknotic nucleus and salmon-pink cytoplasm?

Orthochromic Normoblast

What is the N:C ratio of an Orthochromic Normoblast?

1:2

Which erythroid precursor ejects its nucleus, forming a pyrenocyte?

Orthochromic Normoblast

What nuclear remnant may be seen in Orthochromic Normoblasts?

Howell-Jolly bodies

Where is the Orthochromic Normoblast found?

Bone marrow

What is the bone marrow transit time of an Orthochromic Normoblast?

48 hours

What is the size range (in µm) of a Reticulocyte?

8-10µm

Which erythroid cell lacks a nucleus and has salmon-pink cytoplasm with a bluish tinge?

Reticulocyte

Where is the Reticulocyte located during maturation?

BM (1-2 days), PB (1 day)

What is the cellular activity of a Reticulocyte?

Completes hemoglobin production

What is detected using a supravital stain in reticulocytes?

Residual ribosomal RNA ("reticulum")

What is the bone marrow transit time of a Reticulocyte?

24-48 hours

What is the size of a mature erythrocyte?

7-8µm in diameter, 1.5-2.5µm thick

Which mature erythroid cell lacks a nucleus and appears salmon-pink with 1/3 central pallor?

Mature erythrocyte

Where is the mature erythrocyte found?

Peripheral blood

How long does a mature erythrocyte remain in circulation?

120 days

What is the primary function of a mature erythrocyte?

Oxygen delivery from lungs to tissues

What is the secondary function of a mature erythrocyte?

Carbon dioxide delivery and blood pH buffering