Review Problems - Ceutics E2

chewable tablets are suitable for

-patients with difficulty swallowing

-drugs with a large dose

effects of granulation

-makes powder more compressible

-improves flowability of the powder

-ensures uniform distribution of the API

what should the moisture content of a hard gelatin capsule be

12-16%

strategies to prevent stability issues of a drug in solid dosage forms

-desiccants

-blister packaging

what are vegetable capsule shells prepared with

-HPMC (hypromellose)

what defines the shape and size of tablets (manufacturing)

-dies

film coating

-may be used to mask unpleasant taste

-eudragit S100 may be used to target drug release in colon

primary purpose of film coating of finasteride tablets

-prevent contact with the drug for women of reproductive age

excipients in tablets

-lactose (diluent)

-sucrose (binder)

-polyethylene glycol (plasticizer)

true statements about capsules

-easier to manufacture than tablets

-increase bioavailability of poorly soluble drugs

-may be colored to aid in identification

true statements about hard gelatin capsules

-two types of gelatin with different isoelectric points

-grade of gelatin is defined by bloom strength

ODT counseling point

-place tablet on tongue and wait for it to dissolve

patient that would benefit from ODT

-62 year old with dysphagia

candida infection at which site is best treated with clotrimazole troche

-mouth

benefit of sublingual nitroglycerin administration

-avoids first pass metabolism