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this condition is characterized by the urethral opening being on the ventral surface of the penis
hypospadias
this condition is characterized by the urethral opening being on the dorsal surface of the penis
epispadias
This condition is characterized by the opening of the penile prepuce being too small frequently from repeated infections
phimosis
what is inflammation of the glans and prepuce of the penis
balanoposthitis
what is accumulation of desquamated epithelial cells, sweat and debris in uncircumcised males
smegma
this disease consists of penile plaques from deposition of collagen between corpora cavernosa and tunica albuginea causing curvature of the penis. it is triggered by trauma or vigorous activity
peyronie disease
what is HPV independent malignancy of the penis with white patches on foreskin associated with
balanitis xerotica obliterans
what are the two distinct lesions of HPV associated malignancy of the penis called
Bowen disease and bowenoid papulosis
this disease is in older men, shaft and scrotum affected, solitary gray white plaque or red and velvety on glans and low risk of SCC
Bowen disease
this disease is younger men who are sexually active creating multiple red brown papular lesions which do not progress to invasive SCC
Bowenoid papulosis
this invasive carcinoma of the penis is exophytic, warty, well differentiated, invades locally without mets and is hPV independent
verrucous carcinoma
this invasive carcinoma of the penis is ill defined, gray white ulcerative or endophytic with aggressive and destructive invasion, HPV associated
basaloid squamous carcinoma
this anomaly of the testis occurs when there is an incomplete descent of the testis from the abdomen usually in the inguinal canal
cryptorchidism
this inflammatory condition is characterized by tender testicular mass of sudden onset sometimes w fever, mimics a testicular mass, autoimmune and middle aged men
granulomatous orchitis
this infection is an extension of infection from urethra to prostate , seminal vesicles and then to epididymis and may develop an abscess
gonorrhea
this infection is a systemic viral disease, more common in post pubertal with bilateral involvement causing reduction in fertility
mumps
this disease causes obliterative endocarditis and gummas
syphilis
this congenital anatomical defect where the testicle isn’t secured to the scrotum can cause testicular torsion
bell clapper anomaly
this spermatic cord/paratesticular tumor is associated with a hernia sac where adipose is pulled into inguinal canal
lipoma
this spermatic cord/paratesticular tumor is associated with small nodules near upper pole of epidermis and is the most common benign paratesticular tumor
adenomatoid
this syndrome has components of cryptorchidism, hypospadias, and poor sperm quality and is associated with germ cell tumors
testicular dysgenesis syndrome
what is a precursor lesion to germ cell tumors which arises in utero and remains dormant until puberty and is associated with KIT mutation
germ cell neoplasia in situ
what is the most common type of GCT
seminoma
this tumor is bulky, homogeneous, tan white, no hemorrhage or necrosis, has sheets of uniform cells divided by fibrous septa with lymphocytes
seminoma
this germ cell tumor arises in 20-30s, is locally aggressive, variegated, poorly demarcated, hemorrhage and necrosis and alveolar or tubular patterns with papillary convolutions
embryonal carcinoma
this germ cell tumor is the most common in infants and kids up to 3 y/o, not associated with GCNIS in 3 y/o and has AFP marker
yolk sac tumor
which yolk sac form has this: non encapsulated, homogeneous, yellow white, mucinous w cystic changes, hemorrhage and necrosis
adult form
which yolk sac tumor form has this: homogeneous, solid, yellow/tan, myxoid
kids
what glomeruloid feature microscopically is seen with yolk sac tumors
schiller-duval bodies
this germ cell tumor is highly malignant, mets early to lungs or liver, has hemorrhage and necrosis and syncytiotrophoblasts and cytotrophoblasts
choriocarcinoma
this germ cell tumor has more than one germ layer of cells present, large, heterogeneous, cartilaginous and cystic areas with hemorrhage and necrosis
teratoma
is the prepubertal form or post pubertal form of teratoma pure, benign, and not associated with GCNIS
prepubertal
where do germ cell tumors spread hematogenously
lungs, liver, brain, bones
which germ cell tumor has the best prognosis?
seminomas
this sex cord-gonadal stromal tumor may elaborate androgens, estrogens and corticosteroids with testicular swelling or gynecomastia, is golden brown and circumscribed
leydig cell tumor
what are the round or polygonal cells with rod shapes found in leydig cell tumors called
crystalloids of reinke
this sex cord gonadal stromal tumor is hormonally silent, firm, small, gray white to yellow with cells arranged in trabeculae forming cord like structures
Sertoli cell tumor
what is the most common testicular neoplasm in men > 60 years/o
testicular lymphoma
what is chronic abacterial prostitis referred to as
chronic pelvic pain syndrome
what can BCG treatment for bladder cancer cause in the prostate?
granulomatous prostatitis
dihydrotestosterone binding androgen receptors which encode TGF-B and fibroblast growth factor family causing increased proliferation of stomal cells and decrease the death of epithelial cells is the pathogenesis of what prostatic disease
BPH
this hormone plays a role in BPH by tipping the balance towards proliferation
estrogen
what is the most common form of cancer in men in US
prostatic adenocarcinoma
what genetic alteration occurs in approximately 50% of prostate cancers
TMPRSS2-EGR
What is a precursor lesion to prostatic adenocarcinoma
high grade prostatic intraepithelial neoplasia
where do most prostatic adenocarcinomas arise
posterior in the peripheral zone
where does hematogenous spread of adenocarcinoma of the prostate typically spread
axial skeleton
what is the most common tumor to secondarily involve the prostate
urothelial cancer