[HEMA] Chapter 4 - Hemoglobin Formation

It compromises approximately 95% of the cytoplasmic content of RBC’s.

34 g/dL

HEMOGLOBIN Concentration is approximately______ with a molecular weight of 64,000 Daltons.

64,000 Daltons

Concentration is approximately 34 g/dL with a molecular weight of ___________.

Felix Seyler

In 1862, ___________ identified the respiratory protein hemoglobin.

oxygen dissociation curve

Today, the activities of hemoglobin and oxygen are well-known and can be demonstrated by an ___________.

Deoxygenated state (Tense)

Deoxygenated state (Relaxed)

red blood cell

a chain

B chain

iron

heme gorup

B chain

a chain

helical shape of the polypeptide molecule

Hemoglobin

a tetramer of for globin polypeptide chains, with a heme molecule attached to each chain

Heme

Heme

is protoporphyrin IX that carries a central ferrous ion (Fe2+)

chromosome 16

Alpha and Zeta Globin genes are on the short arm of ________________.

chromosome 11

Epsilon, Gamma, Delta, and Beta Globin genes are on the short arm of ______

erythroid precursors

The production of globin chains takes place in ______________ from the pronormoblast through the circulating polychromatic erythrocyte, but not in the mature erythrocyte.

pronormoblast

The production of globin chains takes place in erythroid precursors from the ______________ through the circulating polychromatic erythrocyte, but not in the mature erythrocyte.

polychromatic erythrocyte

The production of globin chains takes place in erythroid precursors from the pronormoblast through the circulating _____________, but not in the mature erythrocyte.

nucleus

Transcription of the globin genes to messenger ribonucleic acid (mRNA) occurs in the __________.

globin polypeptide chain

Translation of mRNA to the ___________ occurs on ribosomes in the cytoplasm.

141

146

146

146

146

141

Unknown