Link Reaction
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18 Terms
Where does the link reaction occur?
Mitochondrial matrix
What is the link reaction?
The conversion of pyruvate into acetyl CoA
What does the link reaction connect?
Glycolysis to the Krebs cycle
What is another name for the link reaction?
Oxidative decarboxylation
How does pyruvate enter the mitochondrial matrix?
By active transport through carrier proteins
What happens during decarboxylation?
CO2 is removed from pyruvate
What happens to the CO2 produced in the link reaction?
It diffuses out of the mitochondrion
What happens when pyruvate is oxidised?
Two hydrogen atoms are removed
What is formed when hydrogen is removed from pyruvate?
A two carbon acetate molecule
What happens to NAD in the link reaction?
It is reduced by hydrogen to form reduced NAD
What happens to acetate?
It combines with coenzyme A
What is formed when acetate combines with coenzyme A?
Acetyl CoA
What are the reactants of the link reaction?
Pyruvate NAD and coenzyme A
What are the products of the link reaction?
Acetyl CoA reduced NAD and carbon dioxide
What is the role of acetyl CoA?
It delivers the acetyl group to the Krebs cycle
How many CO2 molecules are produced per pyruvate?
One
How many reduced NAD molecules are produced per pyruvate?
One
What happens to pyruvate before the link reaction?
It is actively transported into the mitochondrial matrix