E. coli and sepsis

for med micro project

What is sepsis and how is it related to E. coli?

Sepsis is a severe medical condition in which the body is overwhelmed from an infection that has made its way to the blood. E. coli is a leading cause of bloodstream infections in adults

Who is particularly at risk for E. coli-induced sepsis?

underweight neonates, the elderly, and those with compromised immune systems.

Which bacteria has E. col replaced as the leading cause of early-onset sepsis in neonates?

Group B Streptococcus

What are the common sources of E. coli infections in hospitals?

Catheter-associated urinary tract infections and surgical site infections.

What is endogenous transmission?

Infections that spread from within a person's body.

Where is e. coli usually found in humans?

the gut

What are virulence factors in E. coli strains ExPEC?

Genetic tools that help the bacteria adhere to tissues in the host cell, produce toxins, and evade immune defenses.

What symptoms indicate severe sepsis or septic shock?

Dangerously low blood pressure, low urine output, and signs of organ failure.

What is a cytokine storm?

A massive immune response triggered by infection, leading to inflammation throughout the body.

Why are treatment options becoming complicated for E. coli sepsis?

Due to the increasing resistance of E. coli strains to common antibiotics.

What supportive care may be needed for E. coli sepsis patients?

Fluids, medications to support heart function, oxygen or mechanical ventilation, and dialysis.

How can vertical transmission of E. coli be prevented during childbirth?

By giving mothers antibiotics during labor.

What role does proper hygiene play in preventing E. coli sepsis?

It includes hand washing and sterilizing equipment to reduce infection risk in hospitals.

What are RDW and hematocrit in relation to E. coli sepsis?

Biomarkers that help predict which patients are at higher risk of death.

Why is the surveillance of multidrug-resistant strains urgent?

Due to the increasing appearance of these strains in newborns and adults and the need for updated guidelines.

What is the significance of personalized care strategies in E. coli sepsis treatment?

They enhance the ability to fight the complex condition by understanding host-microbe interactions.

What is the initial approach to treating E. coli sepsis?

Immediate use of broad-spectrum antibiotics until lab tests determine the strain and its susceptible drugs.