Registry 2025 - thresholds and dose response relationships

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4 Terms

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Linear-nonthreshold relationship

-Indicates that no level of radiation can be considered completely safe.

-A response occurs at every dose

- the response is often considered "stochastic effect" (aka: all or nothing)

-The degree of response to exposure is directly proportional to the amount of radiation received.

examples for this relationship

- leukemia

- cancer

- hereditary effects

<p>-Indicates that no level of radiation can be considered completely safe.</p><p>-A response occurs at every dose</p><p>- the response is often considered "stochastic effect" (aka: all or nothing)</p><p>-The degree of response to exposure is directly proportional to the amount of radiation received.</p><p>examples for this relationship</p><p>- leukemia</p><p>- cancer</p><p>- hereditary effects</p>
2
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Linear-threshold relationship

- Indicates that at lower doses of radiation exposure, no response is expected.

- When the threshold is exceeded, the response is directly proportional to the dose received.

Examples for this relationship:

Short-term (somatic, early tissue) effects like skin erythema, sterility, leukopenia

​

<p>- Indicates that at lower doses of radiation exposure, no response is expected.</p><p>- When the threshold is exceeded, the response is directly proportional to the dose received.</p><p>Examples for this relationship:</p><p>Short-term (somatic, early tissue) effects like skin erythema, sterility, leukopenia</p><p>​</p>
3
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Nonlinear-threshold relationship

- indicates that at lower doses of radiation exposure no response is expected.

- when the threshold dose is exceeded the response is not directly proportional to the dose received and is increasingly effective per unit dose.

- the response is predictable and the effects are call nonstochastic

example:

ARS, Cataractogenesis, most teratogenic effects

<p>- indicates that at lower doses of radiation exposure no response is expected.</p><p>- when the threshold dose is exceeded the response is not directly proportional to the dose received and is increasingly effective per unit dose.</p><p>- the response is predictable and the effects are call nonstochastic</p><p>example:</p><p>ARS, Cataractogenesis, most teratogenic effects </p>
4
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nonlinear-nonthreshold relationship

- indicates that no level of radiation can be considered completely safe

- a response occurs at every dose

- degree of response is not directly proportional to the dose received

- the effect is large even with a small increase in dose

example: radiation therapy

<p>- indicates that no level of radiation can be considered completely safe</p><p>- a response occurs at every dose</p><p>- degree of response is not directly proportional to the dose received</p><p>- the effect is large even with a small increase in dose</p><p>example: radiation therapy</p>