Lab 1- BLOOD

Mastrangelo lab 1 (sem 2)

What percentage of blood volume is plasma?

55%

What is plasma composed of?

Water, electrolytes, proteins, hormones, antibodies and nutrients

What is the normal range for RBCs?

4-6 million/ uL

Lifespan of RBCs?

120 days

Normal Hemoglobin range (men)?

14-18 gm/100 mL

Normal Hemoglobin range (women)?

12-16 gm / 100 mL

Large bone marrow cell with lobed nucleus; responsible for platelet production?

Megakaryocyte

Thrombocytes - second most numerous circulating cell in the body?

Platelets

ADP, ATP, seratonin, glutamate, Ca2+, polyphosphate and epineprine?

Dense Granules

Fibrinogen, Fibroconnectin, Thrombospondin, vWF, PDGF, TGF-b, TGF-a, ECCGF, GGF and P-selectin?

Alpha Granules

Steps for platelet activation?

Shape change, granule release, aggregation, adhesion molecule expression

Normal WBC range?

4,500 - 11,000 / uL

Phagocytes with cytoplasmic granules and lobed nuclei?

Granulocytes

No granules and spherical / kidney - shaped nuclei?

Agranulocytes

Neutrophil (55-70%)

Eosinophil (1-4%)

Basophil (0.5-1%)

Lymphocyte (20-40%)

Monocyte (2-8%)

Epithelial cells, monocytes, macrophages, dendritic cells, neutrophils, eosinophils, basophils and mast cells?

Innate Immunity

Th1 cells, Th2, Th17, Th9, Th22, T reg cells, Cytotoxic T cells and B cells?

Adaptive Immunity

NK cells, NKT cells, T cells, Lymphoid cells?

Both Innate and adaptive

What occurs when antigen is mixed with its corresponding antibody?

Agglutination

Condition where body does not get enough oxygen (blood lacks red cells / hemoglobin)?

Anemia

Rare genetic disorder where blood does not clot?

Hemophilia

Alteration in genes affecting VWF

Von Willebrand Disease

How / where are RBCs recycled?

By macrophages in the spleen

OG blood stem cell (precursor to both myeloid and lymphoid progenitors)

Hemocytoblast