BACTO XII: Rickets

What is the full name of rickets

Rickettsiales: genus Ehrlichia; Rickettsia; Anaplasma

Rickettsia size

Very small

Rickettsia shape

coccobacilli

Rickettsia gram stain

gram negative

Rickettsia intra or extracellular

Obligate intracellular parasites (replicate only in the cell of the host)

Rickettsia - treatment

Tetracycline

canine monocytic ehrlichiosis proper name

Ehrlichia canis

canine monocytic ehrlichiosis is a disease in what kind of areas

Disease of dogs in tropical regions

canine monocytic ehrlichiosis - zoonotic?

Not a zoonosis

canine monocytic ehrlichiosis multiples in...

monocytes and macrophages

canine monocytic ehrlichiosis are spread by

Via tick bite
In the tick there is no transmission between ticks

canine monocytic ehrlichiosis diseae peaks when

Disease peaks in the warm-wet season

canine monocytic ehrlichiosis resviours

Wild reservoir: wild/domestic canid: carriers

canine monocytic ehrlichiosis is cytopathic. What does this mean

cells have altered production of cell products

canine monocytic ehrlichiosis is immunopathic. What does this mean

gammopathy; auto-antibody production

canine monocytic ehrlichiosis chronic phase

peripheral oedema (vasculitis); loss of condition; pancytopaenia (bone marrow suppression); hypergammaglobulinemia (polyclonal gammopathy); epistaxis; uveitis; glomerulonephritis

canine monocytic ehrlichiosis subclinical phase

can last years

canine monocytic ehrlichiosis acute phase

ever and lethargy; lameness; ataxia; vomiting; haemorrhages on skin and mucous membranes

What are the three phases of canine monocytioc ehrlichiosis

Acute
Subclinical
chronic

canine monocytic ehrlichiosis diagnosis

Giemsa-stained peripheral blood/bone marrow aspirates: E. canis morulae within mononuclear cells
Detection of a seroconversion; PCR protocols
Serology

Culture for E.canis

Impractical

In endemic regions, empirical treatment with doxycicline often instigated before

a definitive diagnosis is established

Seroconversion

a change in serologic tests from negative to positive as antibodies develop in reaction to an infection or vaccine

canine monocytic ehrlichiosis prevention

tick control

canine monocytic ehrlichiosis treatments

doxycycline (6-8 weeks treatment) + supportive therapy

canine monocytic ehrlichiosis - are reinfections common?

Relapses/reinfections are common

canine monocytic ehrlichiosis is a _____phasic disease

triphasic