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Nervous System
Nervous System communicates via chemical signals called neurotransmitters
CNS (Central Nervous System)
brain
spinal cord
Peripheral nervous system
somatic nervous system
autonomic nervous system
sympathetic nervous system: “fight or flight”
parasympathetic nervous system: “rest and digest”
CNS (Central Nervous System): Brain
Hindbrain
medulla: regulates HR (heart rate), BP (blood pressure) and respiration
pons: controls respiration
cerebellum: coordinates voluntary muscle movement & maintains balance & equilibrium, muscle tone & posture
Midbrain
coordination of vidual and auditory reflexes
Forebrain
cerebral cortex
hypothalamus
amygdala
hippocampus
Limbic System: Stress & Emotional Responses
hypothalamus: releases hormones, linked to emotional functioning
amygdala: general arousal, threat detection
hippocampus: memory (emotional)
CNS involved in SNS activation
SNS activation triggers release of catecholamines (type of neurotransmitter)
epinephrine & norepinephrine
orchestrates a host of systemic (stress-like) responses simultaneously
cardiovascular: increased HR, blood vessel constriction, BP
Respiratory: increased respiration, airflow into lungs
Digestive: decreased digestion and urination
Nervous System: Diseases
epilepsy
parkinson’s disease
cerebral palsy
multiple sclerosis
huntington’s disease
dementia/alzheimer’s disease
amyloid & tau (protein) deposits in the brain
cerebrovascular disease
sleep (lack of) as sleep removes amyloid
Endocrine System
made up of several glands that secrete hormones into the blood stream to stimulate activity in the organs
pituitary glands
and the hypothalamus refulate the endocrine system
adrenal glands
made up of the adrenal medulla & adrenal cortex
secrete hormones implicated in stress response
in response to stress, activation of the HPA axis (hypothalamic-pituitary-adrenal-axis)
Endocrine System: Diseases
diabetes: chronic inability to manufacture or properly use insulin
Type I Diabetes: autoimmune disorder where the immune system erroneously destroys body’s own cells that are needed to produce insulin
early in life
partly genetic
Type II Diabetes: insuff insulin produced by the body
largely lifestyle related
typically happens after 40
comorbid with coronary heart disease & kidney disease
Cardiovascular System
BP (Blood Pressure)
PEP (Pre-ejection period)
CO (Cardiac Output)
TPR (Total Peripheral Resistance)
BP (Blood Pressure)
force on the blood vessel walls from systolic and diastolic processes
systole: heart contracts, pump blood out
diastole: heart relaxes, take in blood
PEP (Pre-ejection period)
time between left ventricle contraction and aortic valve opening
a pure measure of SNS activation
CO (Cardiac Output)
volume of blood pumped per min
indicator of cardiac functioning
TPR (Total Peripheral Resistance)
vascular resistance to blood flow
index of “stiffness” in the arteries
Cardiac Efficiency
High cardiac efficiency
blood pumped quickly (short PEP), in high volumes (high CO) and at low resistance (low TPR)
physically fit individuals
Low cardiac efficiency
blood pumped slowly (low PEP), in low volumes (low CO), at high resistance (high TPR)
physically unfit individuals
Heart-Rate-Variability (HRV)
or vagal tone
is the variation in time between heart beats
variability occurs when the vagus nerve exerts control of the heart i.e. PNS activity
Heart Rate: is the no. of heart beats in 1min (norm is 60-100bpm)
in general, higher HRV (vagal tone) is associated with
better fitness
better adaptability
better cognition
better general health
lower SNS activation in response to stimuli/stressor
higher HRV “car accelerator & brake”: PNS activity is akin to applying a brake to reduce SNS activity. this balancing contributes to inter-beat variability. the amount of such variability is HRV. high HRV indicates body’s ability to continuously balance itself in response to any stimuli.