Cysteine Oxidation Specificity

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6 Terms

1
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How common is cysteine in proteins?

1–2% of all amino acids

2
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Why are some cysteines not oxidised?

They are inaccessible or involved in disulfide bonds

3
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Why are most cysteines not redox sensitive?

They have pKa >8 and are protonated at physiological pH

4
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What makes a cysteine redox sensitive?

Low pKa (3–5.5) and deprotonation

5
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What form is highly reactive in redox signalling?

Thiolate anion

6
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Which nearby amino acids stabilise thiolate formation?

Histidine