Neutrophils

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6 Terms

1
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What is the structure of a neutrophil nucleus?

2–5 lobes connected by chromatin strands.

2
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What are the main granules of neutrophils?

  • Primary (azurophilic) granules – lysosomal enzymes

  • Secondary (specific) granules – enzymes and antimicrobial peptides

3
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What is the first WBC type to arrive at the site of infection?

Neutrophils.

4
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What does a “shift to the left” in Arneth’s formula indicate?

Predominance of immature (hyposegmented) neutrophils – severe infection.

5
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What does a “shift to the right” in Arneth’s formula indicate?

Older hypersegmented cells – megaloblastic anemia.

6
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What are the two mechanisms of microbial destruction by neutrophils?

A. Oxygen-dependent (respiratory burst producing ROS)

B. Oxygen-independent (enzymes and antimicrobial peptides)