Bone pathology

osteogenesis imperfecta

brittle bone disease, type 1 collagen maturation

opalescent teeth, blue sclera, and maxillary hypoplasia associated with

osteogenesis imperfecta

cleidocranial dysplasia

hypoplastic/absent clavicles, supernumerary teeth

focal osteoporotic bone marrow defect is not pathology and does not need treatment 

both statements are true

focal osteoporotic bone marrow defect is not a variation of normal and is asymptomatic

first statement is false second statement is true

idiopathic osteosclerosis radiolucency with no association with inflammation and is associated with teeth

both statements are false

age demographic for patients with paget disease

older patients

paget disease

abnormal/deposition of bone

weakened distorted bones

paget disease clinical/radiographic features

M>F, maxilla, usually asymptomatic, xray- cotton wool appearance

polyostotic

multiple bones affected

monostotic

one bone affected

paget’s disease radiographic appearance

cotton wool 

central giant cell granuloma

common in kids and young adults, mandible, F>M, 1st molar or anterior, uni or multilocular

we see aggressive CGCG more often than we non-aggressive

false

what are the areas with numerous purple circles 

multinucleated giant cells

multinucleated giant cells histology is associated with

CGCG

cherubism associated with

CGCG

histology looks the same 

CGCG, brown tumor of hyperparathyroidism, cherubism

fibro-osseous lesions require clinical and radiographic info along with histology for a specific diagnosis

true

GNAS1 gene associated with 

fibrous dysplasia

fibrous dysplasia most commonly affects the mandible and is M>F

both statements are false 

characteristics of fibrous dysplasia

cafè-au-lait pigmentation (coast line of Maine), ground/frosted glass and radiopaque radiograph

irregular bony trabeculae

irregular bony trabeculae

most common benign fibro-osseous lesion

cemento-osseous dysplasia

focal cemento-osseous dysplasia gender predilection

F>M

focal cemento-osseous dysplasia asymptomatic/symptomatic

asymptomatic

focal cemento-osseous dysplasia radiographic appearance

mixed

periapical cemento-osseous dysplasia location

anterior MD

focal cemento-osseous dysplasia demographic predilection

african women

in periapical cemento-osseous dysplasia teeth are

vital

florid cemento-osseous dysplasia symptomatic/asymptomatic

asymptomatic

florid cemento-osseous dysplasia demographic predilection

middle aged african/asian women

bony trabeculae are associated with

fibrous dysplasia

cemento-osseous dysplasia gender predilection

F>M

cemento-osseous dysplasia radiographic appearance

progressive RL —> RO

osteoma radiographic appearance 

RO

how do you diagnose paget disease

increased alkaline phosphatase

paget disease tx

bisphosphonates

frosted/ground glass appearance aside from fibrous dysplasia

psammomatoid - juvenile ossifying fibroma

most common primary malignant tumor of bone

osteosarcoma

radiographic sunburst appearance

osteosarcoma

garrington’s sign

widening of PDL space

what is garrington’s disease seen in

osteosarcoma

what can often be the first sign of cancer

metastatic lesions

radiographically looks moth eaten

metastatic lesions

multiple osteomas =

gardner syndrome

lymphoid hyperplasia is

reactive

punched out radiolucencies, teeth floating in air

langerhans’ cell histiocytosis

birbeck granules associated with

langerhan’s cell histiocytosis

reed sternberg cells associated with

hodgkin lymphoma

stage 1 of hodgkins lymphoma involves

a single lymph node or organ site

stage 2 of hodgkins lymphoma involves

2 or more lymph node involvement on same side of diaphragm 

stage 3 of hodgkins lymphoma involves

lymph node regions with dual diaphragm involvement

non-hodgkin lymphoma

malignancy of lymphocytes

non-hodgkin lymphoma arises from

B cells

associated with epstein barr virus (EBV)

burkitt lymphoma

pt who have multiple myeloma secrete high amount of protein products in the urine called 

bence-jones proteins

pt who have multiple myeloma are usually on 

bisphosphonates

multiple myeloma radiographic appearance

punched out