[BB] OTHER MAJOR BLOOD GROUPS

Lewis antigen

Not a true blood group antigen

"Plasma antigens"

Glycoproteins

Lewis antigens found in secretions are

Glycolipids

Lewis antigens found in plasma are

Leb antigen

Receptor for helicobacter pylori

Lewis positive gene

Converts the precursor material to Le a

Lewis

Blood group that can react in ANY phase of testing

Le (a-b+)

The most common Lewis phenotype

Glycophorin A

MN antigens are located at:

Glycophorin B

Ss antigen is located at:

Position 1 and 5

MN antigens differ in amino acid at what position

1-Serine, 5-glycine

Amino acid in M antigen at position 1 and 5

1-Leucine, 5-glutamate

Amino acid in N antigen at position 1 and 5

MN

MNSs antigens: easily destroyed or removed by enzymes

Ss antigens

MNSs antigens- less easily degraded by enzymes

VARIABLE IN FICIN TREATMENT

Position 29

Ss antigens differ in amino acid at what position

Methionine

S antigen amino acid at position 29

Threonine

s antigen amino acid at position 29

U antigen

located near membrane; present when S or s is inherited

RESISTANT TO FICIN

6.5

Anti-M reacts best at what ph

Anti-N

MNSs antibody seen in renal patients, who are dialyzed on equipment sterilized with FORMALDEHYDE

Anti-S/s

MNSs antibody implicated in SEVERE HTR with HEMOGLOBINURIA

LKE

Associated with metastasis in RENAL CEL CARCINOMA

P2

Individuals whi lack P1 are termed

P blood group

"The cool one"

Human parvovirus B19

P is the receptor of what virus

P1 antigen

Deteriorates rapidly on storage

P1 like antigen

Found in plasma, and droppings of pigeons, turtle doves, egg white of turtle doves

Echinococcus granulosus

Strong anti-P1 is observed with individuals infected with what parasite

Anti-Tja

also known as anti-PP1Pk

IgG or IgM

associated with spontaneous abortion, HDFN, DHTR

inhibited by P1

Autoanti-P

Antibody associated with Paroxysmal cold Hemoglobinuria (Biphasic IgG antibody)

Donath-Landsteiner test

the diagnostic test for PCH

Anti-Pk

Has been reported in the serum of P1 individuals with biliary cirrhosis and autoimmune hemolytic anemia

Autoanti-I

what antibody is associated with mycoplasma pneumoniae and cold hemagglutinin disease?

Anti-I

Common cause of positive autocontrol

Anti-i

associated with infectious mononucleosis, alcoholic cirrhosis and myelogenous leukemia

Kell

Second most immunogenic blood group outside of abo

DTT, ZZAP, 2-AET, and glycine-acid EDTA

Sulfhydryl reagents

K antigen

Easily destroyed by sulfhydryl agents

McLeod phenotype

Associated with weak Kell system

antigenic expression

A. McLeod phenotype

B. MS

C. Kpa

D. Ss

CGD

absence of Kx from leukocyte is seen in individuals with

Acanthocyte

McLeod syndrome causes a chronic, well compensated hemolytic anemia characterized by the presence of this cell morphology:

Duffy gene

First human gene to be assigned to a specific chromosome

ACKR1

Duffy glycoproyein is a member of the superfamily of chemokine receptors and is known as

Fy a

Fy b

Fy6

Duffy antigens that are sensitive to ficin

Fy3

Fy5

What are the Duffy antigens that are RESISTANT to ficin or papain treatment?

Position 42

Fy a and Fy b differ in amino acid at what position

Glycine

Amino acid of Fy a at position 42

Aspartic acid

Amino acid of Fy b at position 42

Fy (a+b-)

predominant duffy ag in asians (mostly chinese)

Fy (a+b+)

What is the most common duffy phenotype in the white population?

Fy (a-b-)

This is a very rare phenotype that is found in mostly blacks and results in the lack of an Fy6 receptor which makes cells resistant to malaria.

RBC urea transporter

Where are the Kidd antigens located?

11 weeks Jka

7 weeks Jkb

Jk antigens are present on fetal red cells as early as how many weeks for Jka and Jkb

Jk (a-b-)

RBCs are resistant to lysis by 2M urea:

A. Le (a-b-)

B. Fy (a- b-)

C. Jk (a-b-)

D. Jk (a+b+)

Kidd

Blood group that causes delayed HTR

Anti-Lu(a)

Lutheran antibody that has a characteristic mixed field pattern of agglutination

Anti-Lu(b)

Lutheran antibody that is CLINICALLY SIGNIFICANT

Anti-Lu3

Only true Lutheran null phenotype individuals produce this antibody: