heme II: hemolytic anemias

what is acute hemolysis

sudden onset, disappears in episodes, paroxysmal

what is chronic hemolysis

worsens over time, may not be evident if bone marrow can compensate, g6pd def.

which type of hemolysis occurs within the cell

intrinsic

which kind of hemolysis occurs outside the cell (in the plasma)

extrinsic

what kind of hemolysis is characterized by schistocytes

intravascular

which kind of hemolysis is characterized by spherocytes

extravascular

hereditary spherocytosis is a defect in ___ that disrupts ___ interactions

spectrin, vertical

spherocytes lead to

increased osmotic fragility

hereditary elliptocytosis is a defect in ___ that disrubts ___ interactions

ankrin, horizontal

hereditary ovallocytosis is also known as

southeast asia ovalocytosis

SAO can help with resistance to

malaria

which of the following is not a membrane abnormality condition

hereditary stomatocytosis

what is hereditary stomatocytosis

an imbalance of cations, leading to the leakage of the RBC membrane

abetalipoproteinemia is characterized by

acanthocytes

a defect in the lipid component of the membrane can lead to the formation of

acanthocytes

the lack of CD55 and CD59 is characteristic of

paroxysmal nocturnal hemoglobinuria

a patient has hemoglobinuria, hemosiderinuria and pancytopenia. what condition is most likely

PNH

G6PD is important in the formation of

NADPH

pyruvate kinase is important in the formation of

ATP

what is the role of glutathione

it detoxifies H2O2

fava beans can trigger a

G6PD deficiency

which condition can heinz bodies be characteristic of

G6PD deficiency

decreased ATP leads to

increased 2,3-BPG

decreased oxygen affinity is characteristic of

pyruvate kinase deficiency

echinocytes are found in what condition

pyruvate kinase deficiency

how do you differentiate spherocytes due to hereditary condition from a MAHA condition

hereditary conditions result in a negative DAT test

in HS, a characteristic abnormality in the CBC results is

increased MCV

the altered shape of the spherocyte in HS is due to

a mutated RBC membrane protein affecting vertical protein interactions

which of the following sets of results is consistent with HS

increased osmotic fragility, negative DAT result

the RBCs in HE are abnormally shaped and have unstable cell membranes as a result of

defects in horizontal membrane protein interactions

acanthocytes are found in association with

abetalipoproteinemia