Joshi Schizophrenia Kahoot

Which of the following G proteins is coupled with D2 receptor?

a. Gi

b. Gs

c. Ga

d. Go

a.

Which of the following is a typical antipsychotic drug?

a. Aripiprazole

b. Clozapine

c. Risperidone

d. Trifluperidol

d.

What is the major mechanism of 1st generation antipsychotic drugs?

a. decrease cAMP

b. increase cAMP

c. block 5HT receptors

d. activate 5HT receptors

b.

Which of the following is the major beneficial effect of the typical antipsychotic drugs?

a. improve positive symptoms

b. improve cognitive symptoms

c. improve negative symptoms

d. none of the above

a.

Which of the following is the major MOA of haloperidol?

a. 5HT receptor antagonist

b. 5HT receptor agonist

c. D2 receptor antagonist

d. dopamine receptor agonism

c.

SAR studies showed that addition of fluorine in the first generation antipsychotic drug:

a. decrease the potency

b. enhance the potency

c. modulates PK activity

d. reduced the antipsychotic activity

b.

Which of the following is a first generation antipsychotic drug, has the longest half life, and is good for maintenance therapy?

a. thiothixene

b. haloperidol

c. pimozide

d. triflupromazine

c.

Which of the following dopamine pathways is affected by antipsychotic drugs to cause EPS?

a. mesolimbic pathway

b. mesocortical pathway

c. tuberoinfundibular pathway

d. nigrostriatal pathway

d.

Which of the following dopamine pathways is affected by antipsychotic drugs to cause hyperprolactinemia?

a. mesolimbic pathway

b. mesocortical pathway

c. tuberoinfundibular pathway

d. nigrostriatal pathway

c.

Which of the following dopamine pathways is responsible for gynecomastia and amenorrhea by antipsychotic drugs?

a. mesolimbic pathway

b. mesocortical pathway

c. tuberoinfundibular pathway

d. nigrostriatal pathway

c.

Which of the following is the BBW for typical antipsychotic drugs?

a. increased mortality in elderly with dementia

b. increased menstrual irregularities/infertility

c. increased metabolic disorder and weight gain

d. increased hemodynamic effects

a.

Which of the following is an atypical antipsychotic?

a. penfluridol

b. molindone

c. risperidone

d. haloperidol

c.

Which of the following receptors activity is the reason of orthostatic hypotension by antipsychotic drugs?

a. alpha adrenergic receptor antagonist

b. ACh receptor agonism

c. alpha adrenergic receptor agonist

d. beta adrenergic receptor antagonist

a.

Which of the following antipsychotic drugs leads to agranulocytosis and requires hematological monitoring?

a. thioridazine

b. haloperidol

c. aripiprazole

d. clozapine

d.

Which of the following drugs may increase sedative effects of antipsychotic drugs?

a. phenytoin

b. prazosin

c. chlorpheniramine

d. atenolol

c.

In which of the following cases should antipsychotic drug be stopped immediately and provide dopamine agonist?

a. agranulocytosis

b. NMS

c. orthostatic hypotension

d. akathisia

b.

I missed 2 of the exact questions but they were about:

• reduced risk of EPS with atypical antipsychotics

• MOA of atypical antipsychotics

• compared to typical antipsychotics, atypical have a reduced risk of EPS

• MOA of atypicals: Weak D2 receptor antagonists, potent 5-HT2 antagonist and 5HT2A inverse agonists