Antibody Diversity

Immunoglobulin genes

Ig polypeperide chains are encoded by gene segments that are rearranged during B-cell development to assemble a functional gene that encode either light or heavy chain.

These gene segments include Leader (L), Joining (J), and Diversity (D) in addition to the V and C gene segments.

Which chromosome encodes the light chains?

K- chain - chromosome #2

Lamba -chain - chromosome #22

Which chromosome encodes the heavy chains?

Chromosome #14.

Somatic recombination

It’s a process of gene rearrangement during the development of B cells to create a functional gene.

Which gene segments make up the V region of the light chain?

V and J

Which gene segments make up the V region of the heavy chain?

V, D, J