Su: Anti-HIV Cytochrome Inhibitors

still lecture 1

what drug is this

cobicistat

cobicistat is an analog of which HIV protease inhibitor?

ritonavir

what changes to ritonavir lead to the formation of cobicistat?

Valine moiety is exchanged for a 2-morpholinoethyl group, and the backbone hydroxyl group is removed

cobicistat does not have any activity against ___

HIV protease

cobicistat can inhibit which CYP

CYP3A4

cobicistat is able to ____ the plasma conc of other co-admin anti-HIV drugs WITHOUT causing cobicistat resistant mutations in the HIV virus

increase

cobicistat is able to ____ the plasma conc of other co-admin anti-HIV drugs WITHOUT causing ______ in the HIV virus

cobicistat resistant mutations

can you use cobicistat alone to treat HIV

hell no that shit dont have any anti-HIV properties by itself #lameasf

cobicistat inhibits intestinal transport proteins which leads to…

increased overall absorption of several anti-HIV medications

cobicistat inhibits liver enzymes that are responsible for inhibiting which HIV integrase inhibitor?

Elvitegravir (EVG)

cobicistat + elvitegravir leads to…

higher concentrations of Elvitgravir are achieved in the body with lower dosing, and enhance Elvitgravir's viral suppression while diminishing its adverse side effects

what is the four drug, fixed dose combo HIV treatment

Elvitegravir/ Cobicistat/ Emtricitabine/ Tenofovir

the quad pill is also known as

stribild

what are the medications that are in the quad pill/ stribild

Elvitegravir/ Cobicistat/ Emtricitabine/ Tenofovir