NU553 Unit 3 Anxiety Disorders Advanced Pharmacology and Pharmacotherapeutics Exam 2

Minimum duration for Generalized Anxiety Disorder diagnosis?

6 months

Number of symptoms required for Generalized Anxiety Disorder in adults?

3 symptoms

Number of symptoms required for Generalized Anxiety Disorder in children?

1 symptom

Core feature of panic disorder?

Recurrent unexpected panic attacks

Core feature of social anxiety disorder?

Fear of social or performance situations

Fear of places where escape is difficult?

Agoraphobia

Primary inhibitory neurotransmitter in anxiety?

Gamma aminobutyric acid

Neurotransmitter linked to panic disorder arousal?

Noradrenergic system

Common medical causes of anxiety?

Hyperthyroidism cardiovascular disease vitamin B12 deficiency

Substance that can cause anxiety symptoms?

Caffeine

Goal of anxiety treatment?

Remission

Physiologic symptoms of Generalized Anxiety Disorder?

Restlessness fatigue poor concentration irritability muscle tension sleep disturbance

Time to peak of panic attack?

Minutes

Number of symptoms for panic attack diagnosis?

4 or more

Duration of concern for panic disorder?

At least 1 month

Best psychotherapy for Generalized Anxiety Disorder?

Cognitive behavioral therapy

Time to assess medication response in anxiety?

4 to 8 weeks

Duration of therapy after remission?

12 months

First-line medications for Generalized Anxiety Disorder?

Selective serotonin reuptake inhibitors serotonin norepinephrine reuptake inhibitors

Selective serotonin reuptake inhibitor with early response?

Paroxetine

Selective serotonin reuptake inhibitor with more weight gain and sexual dysfunction?

Paroxetine

Jitteriness syndrome meaning?

Initial increased anxiety agitation

Risk combining selective serotonin reuptake inhibitors with tricyclic antidepressants?

Toxic drug levels

Serotonin norepinephrine reuptake inhibitor used first-line with depression?

Venlafaxine

Serotonin norepinephrine reuptake inhibitor useful for pain?

Duloxetine

Venlafaxine monitoring parameter?

Blood pressure

Tricyclic antidepressant used for anxiety?

Imipramine

Major tricyclic antidepressant risk?

Cardiac toxicity

Tricyclic antidepressant contraindication?

Narrow angle glaucoma

Benzodiazepine mechanism?

Enhances gamma aminobutyric acid activity

Recommended benzodiazepine duration?

2 to 4 weeks

Why not use benzodiazepines long term?

Dependence tolerance withdrawal

Preferred benzodiazepines in liver disease?

Lorazepam oxazepam

Rapid onset benzodiazepine?

Diazepam

Rebound anxiety meaning?

Symptoms return worse

Antidote for benzodiazepine overdose?

Flumazenil

Flumazenil major risk?

Seizures

Buspirone mechanism?

Partial serotonin receptor agonist

Buspirone onset?

2 to 4 weeks

Buspirone advantage?

No abuse potential

Buspirone limitation?

No immediate relief

Drug interaction with alprazolam?

Azole antifungals increase levels

Monoamine oxidase inhibitor major risk?

Hypertensive crisis

Foods to avoid with monoamine oxidase inhibitors?

Cheese wine soy sauce

Monoamine oxidase inhibitor washout period?

2 weeks

Performance anxiety drug?

Propranolol

Alpha agonist for anxiety?

Clonidine

First-line for social anxiety disorder?

Selective serotonin reuptake inhibitors or venlafaxine

Benzodiazepine approved for panic disorder?

Alprazolam

First-line for children with anxiety?

Selective serotonin reuptake inhibitors

Selective serotonin reuptake inhibitor to avoid in pregnancy?

Paroxetine

Management of selective serotonin reuptake inhibitor sexual dysfunction?

Reduce dose or switch drug

Benzodiazepine taper schedule?

Reduce by 10 percent every few days

Selective mutism definition?

Failure to speak in certain situations

Psychic symptoms of anxiety?

Worry fear apprehension

Somatic symptoms of anxiety?

Tremor sweating increased heart rate

Best combined therapy approach?

Cognitive behavioral therapy plus medication

Why start selective serotonin reuptake inhibitors low?

Prevent worsening anxiety

Most toxic antidepressants in overdose?

Tricyclic antidepressants

Role of atypical antipsychotics in anxiety?

Adjunct only

Benzodiazepine withdrawal symptoms?

Anxiety insomnia irritability muscle issues

Medication similar to lorazepam for anxiety?

Pregabalin

Risk combining benzodiazepines with alcohol or opioids?

Respiratory depression death

Key counseling for selective serotonin reuptake inhibitors?

Symptoms may worsen early

Why avoid benzodiazepines long term?

Dependence tolerance withdrawal

Best drug for anxiety with substance use history?

Buspirone

First-line treatment for anxiety disorders?

Selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors

What makes generalized anxiety disorder diagnosis incorrect?

Duration less than 6 months

Panic attack vs panic disorder?

Single episode vs recurrent with concern

Why avoid paroxetine?

Weight gain sexual dysfunction pregnancy risk

Which drug for performance anxiety?

Propranolol

Why avoid monoamine oxidase inhibitors?

Interaction risks

Duration of treatment after remission?

12 months

Hallmark of generalized anxiety disorder?

Persistent excessive worry

Hallmark of social anxiety disorder?

Fear of social situations