[PCOL-FIN-02-PT2] ANTIDEPRESSANTS

THIS FLASHCARDS IS ABOUT [PCOL] DRUGS OF ANTIDEPRESSANTS.

SSRIs

This is the 1st line treatment for depression.

SERT

MOA of SSRIs:

Selectively inhibits 5-HT reuptake via inhibiting the?

• Fluoxetine

• Fluvoxamine

• Paroxetine

• Sertraline

• Citalopram

• Escitalopram

What are the (6) Common SSRIs Drugs?

Hint: FF-Paro-Ser-Cita-Es

Serotonin syndrome

SSRIs are contraindicated in patients with?

Info

Some studies states that between serotonin and norepinephrine, serotonin is much more associated to depression because this is a happy pill.

• Insomnia

• Increased anxiety

• Irritability

• Sexual dysfunction

• Nausea and vomiting

• Diarrhea

What are the (6) Adverse Effects of SSRIs?

Hint: In-In-Irri-SD-NV-Dia

• Insomnia

• Increased anxiety

• Irritability

What are the (3) Side Effects of SSRIs to the Brain?

Hint: Triple I (iii)

Sexual dysfunction

What is the Side Effect of SSRIs to the Spinal Cord?

Hint: SD

Nausea and vomiting

What is the Side Effect of SSRIs to the CNS?

Hint: NV

Diarrhea

What is the Side Effect of SSRIs to the GIT?

Hint: Diary

• Depression

• PTSD

• Generalized anxiety

• OCD

What are the (4) Miscellaneous Effects of SSRIs (Clinical Applications)?

Hint: DP-GO

Prozac

In SSRIs, fluoxetine is marketed under what brand name?; it manifest higher suicidal tendency.

Fluoxetine (Prozac)

This is the only FDA-approved drug for the treatment of depression among adolescents.

SNRIs

This is the 2nd line treatment for depression.

• Serotonin (5-HT)

• Norepinephrine

MOA of SNRIs:

Inhibits the reuptake of these (2) neurotransmitter.

• Duloxetine (hepatotoxic)

• Venlafaxine (cardiotoxic)

• Desvenlafaxine

• Lemomilnacipram

What are the (4) Examples of SNRIs?

Hint: Du-Ven-Des-Lem

• Depression anxiety

• Panic disorder

• Neuropathic pain

What are the (3) Clinical Applications of SNRIs?

Hint: Dep-Pan-Neu

Norepinephrine

Neuropathic pain is associated to what neurotransmitter?; used as a treatment for tihs.

Increased BP (a1) and HR (B1)

What are the (2) Adverse Effects of SNRIs?

Info

• Increased BP (a1; vasoconstriction)

• Increased HR (B1; positive chronotropy and dromotropy)

TCAs

This class of antidepressant has a narrow therapeutic index; it has 3 cyclic rings that is connected together.

• Serotonin (SERT)

• Norepinephrine (NET)

MOA of TCAs:

Inhibits reuptake of both?

Info

The TCAs activity is much selective in norepinephrine (transporter) than in serotonin; it also has anti-HAM activity (adverse effects).

• Amitriptyline

• Amoxapine

• Clomipramine

• Doxepin

• Imipramine

• Maprotiline

• Nortriptyline

• Protriptyline

What are the (8) Examples of TCAs?

Hint: Ami-Amo-Clo-Dox-Imi-Ma-No-Pro

• Depression

• Neuropathic pain (Amitriptyline)

• Insomnia (Doxepin)

What are the (3) Clinical Applications of TCAs?

Hint: De-Neu-In

H₁ receptor

Insomnia is due to the blockade of this receptor causing sedation.

• Orthostatic hypotension

• Sedation

• Anticholinergic

• QT prolongation

• Weight gain

What are the (5) Adverse Effects of TCAs?

Hint: Or-Se-An-QT-WG

Alpha receptor

Orthostatic hypotension is due to the blockade of what receptor?

Weight gain

What is the common side effect of TCAs due to the blockade of H₁ receptors resulting to increased appetite?