Ketone bodies

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6 Terms

1
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What are ketone bodies?
FA oxidation --> Acetyl CoA --> CAC
- ketone bodies made in liver are acetyl coA
2
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What is D-beta-hydroxybutyrate, acetone, and acetoacetate
Metabolic fuel for heart skeletal muscle and brain
- under starvation when glucose is depleted
3
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Order of fuel molecule use

  • if need ATP

  • in liver which works to provide fuel to toher tissues

  1. circulating glucose

  2. glycogen stores

  3. gluconeogensis

  • uses oxaloacetate from CAC to make glucose and eventually depeltes all of oxaloacetate which shuts down CAC

  1. FA oxidation --> acetyl-coA --> CAC, acetyl-CoA --> ketone body formation

4
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Formation of ketone bodies

  • condensation of two molecules of acetyl coa

  • requires a third acetyl coa molecule, which is released in the end

5
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what does the formation fo ketone bodies produce
acetoacetate, which is reduced to form d-beta hydroxybutryate
6
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What ist he major issue with ketone bodies
Acidosis
- hihg levels of ciruclating acetoacetate and d-beta-hydroxybutryate
- in target tissues, ketone bodies are broken down into two acetylcoa-