INHIBITION OF NUCLEIC ACID SYNTHESIS

Fluoroquinolones

Inhibition of bacterial DNA synthesis by blocking of DNA gyrase and topoisomerase IV

1st generation

nalidixic acid

2nd generation

3rd generation

levofloxacin

4th generation

moxifloxacin

• N&V, diarrhea

• HA or dizziness

• Phototoxicity

• Cartilage erosion (arthropathy)

• Contraindicated to patients with arrythmia

• Drug interactions with antacids and cations

Adverse Effects

rifampin

isoniazid

pyrazinamide

ethanbutol

Dapsone

• Leprosy

• SE: hemolytic anemia, gastrointestinal intolerance, fever, itching, and rashes

Metronidazole

• Antiprotozoal and for bacterial anaerobic infections 

• SE: Stomatitis, diarrhea, and nausea

Nitrofurantoin

• Urinary antiseptic 

• SE: GI distress

Penicillin

Penicillium chrysogenum

Bacitracin

Bacillus subtilis

Chloramphenicol

Streptomyces venezuelae

Erythromycin

Streptomyces erythreus

Lincomycin

Streptomyces lincolnensis

Vancomycin

Streptomyces orientalis

Daptomycin

Streptomyces roseosporus

Streptomycin

Streptomyces griseus

Rifamycin

Streptomyces mediterranei