Human Papillomavirus

Human Papillomaviruses

• Non enveloped, double stranded DNA Virus

• Route: intimate contact; direct skin to skin contact, contaminated surfaces and objects

Badal Keratinocytes

primary targets for HPV infection

Mosaic

warts that coalesce into large plaques

Flat warts

skin colored or pinkish to brown relatively smooth surfaced slightly

elevated flat-topped papules; HPV types 3 and 10

Butcher’s Warts

extensive verrucous or cauliflower like lesions on the dorsal,

palmar and periungual aspects of the hand and fingers

Epidermodysplasia verruciformis (EV)

widespread, discrete or confluent papules that resemble flat warts

Condylomata Acuminata

discrete, sessile, smooth-surfaced exophytic papillomas SOP- external genitalia and the perineum

Condylomata Plana

flat or cervical warts

Bowenoid papulosis

multiple red brown papules or confluent plaques in the external genitalia; HPV 16

Erthroplasia of Queryat

well-demarcated, velvety, erythematous

plaque on glabrous skin; HPV 16

Buschke-Lowenstein Tumor

“semi malignant” verrucous carcinomas; low

risk HPV types 6 or 11

Insect bites

Immediate reactions: histamine, serotonin, formic acid or kinins

 Staphylococcal infections more common

 Lesions: 2-8mm, erythematous urticarial papules; (+) pruritic

 Most frequent in children 2-10 years of age