Radionuclide Generators & Their Quality Control

What is the concept of a parent radionuclide?

ong-lived parent radionuclide is allowed to decay to its short-lived daughter radionuclide and the latter is chemically separated in a physiological solution.

What is the daughter isotope for Tc-99m?

Mo-99m

What is the duaghter isotope of Rb-82?

Sr-82

What is the daughter isotope of Ga-86?

Ge-68

What are the two currently manufactures of Mo-99/Tc-99m Generators?

• BMS (Dupont)

• Curium

What are the types of generators?

• Wet Column Generators

• Dry Column Generators

Does the wet column generator have a large saline reservoir?

True

Is the wet column generator bathed in saline continously?

True

Is the wet column generator volume deteremined by size of evaucauated vial?

True

Is the wet column generator manufactured by Mallinckrodt and GE?

True

Is the wet column generator volume delivered never known?

True

Do you have to assay 1 ml to get the concentration activity for the wet column generator?

True

Is there head space in vial for concentration adjustments in the wet column generator?

No

What is radiolysis?

radiolysis creates peroxides and free radicals (enemies of reduction)

Does the dry column generator has a fixed small saline charge (5.8)?

True

In a dry column is there a 30 ml evacuated vial draws saline through generator followed by air that “dries” column?

True

What are the advantages of a dry column generator?

• volume always known

• Simple assay vial/ml=concentration

• ample head space in vial

• Colum is dry

Is there no radiolysis in a dry column generator?

True

How to elute a dry column generator?

1. Place saline first vial

2. place shielded evacuated vial

3. watch saline bubbles

4. Leave on generator a few minutes

What is the half-life for Molybdenum?

66 hours half-life

What is the decay mode for molybdenum 99?

beta and gamma emission

What is the energy levels for Molybdenum