SARS-CoV-2 , HCV , HSV-1

Three classes of viruses:

DNA, RNA (non-retroviral), and RNA retroviruses

Remdesivir MOA

approved agent for SARS-CoV-2 and inhibits the RNA-dependent RNA polymerase

Molnupiravir MOA in  SARS-CoV-2.

not a RNAPol inhibitor, but rather gets incorporated and leads to “viral error catastrophe” or “lethal mutagenesis.”

Paxlovid MOA

contains a protease inhibitor (nirmatrelvir) and ritonavir, which acts as a CYP3A4 inhibitor to slow the metabolism of the protease inhibitor.

Protein targets in HCV

NS3- NS4A, NS5B, and NS5A

NS3-NS4A function and ending

-previr

protease

NS5B function and ending

-buvir

RNA Polymerase

NS5A function and ending

-asvir
Function not entirely understood

Valcyclovir MOA

prodrug';valine ester on valcyclovir makes it a substrate for peptide transporters. (higher bioavailability)

Valcyclovir vs acyclovir

Valacyclovir is converted to acyclovir in the liver by esterases.