MED ORG LEC - Chemotherapeutic Drugs (ATP FINALS)
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20 Terms
Beta-lactam ring
Structure that is common among all Penicillins
6-APA
Core structure of Penicillin
Amide group
Group essential for the pharmacodynamic activity of penicillin
Amino Group
Structure/group which confers oral activity to cephalosporins
Avibactam
Beta-lactamase (suicide substrates) inhibitor that has a diazabicyclooctane ring
Alkoxy on C7
What group on the cephalosporin structure helps with resist lactamase/?
Nephrotoxicity
Major toxicity associated with aminoglycosides
C4 dimethylamino group
Structure essential for tetracycline activity
FALSE
True or False?
Polyenes are fungistatic in nature
Flucytosine
This is converted to 5-fluorouracil once taken up by fungi
Undecylenic acid
Castor-derived antifungal
Polyenes
Chemical Class of Amphotericin B
Fungal cell membrane injury
MOA of Amphotericin B
Echinocandins
Chemical Class of Anidulafungin
β-1,3-glucan synthase blocker
MOA of Anidulafungin
Nitazoxanide
Aromatic ester amide with thiazoline moiety
Presence/absence of quinuclidine ring
Main structural difference between natural and artificial quinolines
Artemotil
Lipid soluble derivative of Artemisinin
Benzimidazoles
Most recognizable anthelmentics belong to this chemical class
Reverse transcription
Unique process to retroviral (HIV) life cycle and inhibition target of most antiretrovirals