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Humeral/ Antibody mediated specific immunity.
B cells
Cell mediated specific immunity
T Cells
The bodys ability to react with pathogens.
Immunicompentence.
Antigenic detemrint/areas on the molecule where anibodies bind.
Epitopes.
immunoglobulins produced by plasma cells, made of two light chains and two heavy chains.
Antibodies.
Blood fraction rich in antibodies
Gamma globulin.
Main class of antibodies found in blood, and serum, produced un laergested quality during secondary immune responses, only immunoglobulin that crosses placenta, protection against bacteria, viruses, toxins, involved with compliment system, and phagocytosis, acts as a opsonin.
IgG
10-15% of anibodies in serum BUT most in the BODY, most common in mucus membranes, alternative compliment system.
IgA
1st antibody sectreated during primay immune response, found on Bcell membranes, responsible for ABO blood typing, compliment system activation.
IgM
Secreated by basophils and mast cells, Hypersensitivty type.1 reactions
IgE
BCell lymphocytes in bone marrow, antibody mediated.
1) Bcells develop into plasma cells after contact with pathogen,
2) Bcells with IgM on their surfaces bidning to singaling protiens=BCR complex
3) memory cells are produced.
Humeral immunity
immune response intensifying after 2nd exposure
Anemesitc response.
TCell lymphocytes( NKCells, suppresser cells,)
Secrete lymphokines which lead immune response.
Includes: NkCells, Dendritic cells, CD8 cytoxic Tcells
Cell mediated immunity
Repsond to MHC class 2, role is to assit Bcells and cytotoxic CD8 t cells by sending lmyphokines/cytokines to tell bcells to produce antibodies and singal these cells how to fight a pathogen
CD4 helper Tcells
Responding to MHC class type 1 and directly kill tumor cells.
CD8 cytotoxic Tcells.
Chemical messengers within the immune system also referred to as interlukeins.
Cytokines
These moelcules incude the mirgration of luekocytes and are produced by marcophages.
Chemokines
