Chylomicrons

Smooth ER

Free fatty acids (from food) enter the _ to create triglycerides

Rough ER

Triglycerides move to the _ via MTTP to create primordial chylomicrons

Primordial Chylomicrons

Apo B48 or ApoA4

ApoB48

Made of mostly cholesterol

ApoA4

Made of triglycerides and cholesterol

Prechylomicron

Apo B48 and ApoA4

Golgi Apparatus

The pre chylomicron enters the _ to become a nascent chylomicron

Nascent Chylomicron

ApoB48, ApoA4, ApoA1

Enterocyte

Food enters the _ where fat gets metabolized in the small intestine

Lymphatic System

The nascent chylomicron leaves the Golgi apparatus to the _

ApoB lipoprotein

Insulin slows _ translation

MTTP

Insulin blocks _

Denovo lipogenesis

Insulin promotes _ and inhibits lipolysis

Triglycerides

Chylomicron secretion comes from _ (from food) during the Postprandial State

Lipid droplets

Chylomicron secretion comes from _ from stored fat during the Postabsorptive State

Gut

Lipid release from the _ can take up to 6-10 hours

Lipid storage

During Postprandial Lipemia, _ is affected

Chylomicrons and VLDL

Insulin Resistance increases _ (ApoB48 and ApoB100) in blood and tissues

Triglycerides

High levels of _ can cause a risk of CVD

ApoB48

High _ can cause high cholesterol particles, leading to Atherosclerosis

Atherosclerosis

Plaque build up in arteries

General circulation

Nascent chylomicrons enter the lymphatic system in order to enter the _

Left subclavian vein

Nascent chylomicrons pass into the venous system (from the LS) at the _

Heart, lungs, general circulation

Nascent chylomicrons pass through the _ to become oxygenated before reaching the liver

Exogenous lipid pathway

Transports dietary lipids from intestine to the body via chylomicrons

Endogenous lipid pathway

Transports of lipids synthesized in the liver to peripheral tissues via VLDL