8. T Cell Responses (Incomplete)
Call Kai
Learn
Practice Test
Spaced Repetition
Match
Flashcards
Knowt Play1/30
There's no tags or description
Looks like no tags are added yet.
Name | Mastery | Learn | Test | Matching | Spaced | Call with Kai | Chat |
|---|
No analytics yet
Send a link to your students to track their progress
31 Terms
Where do T lymphocytes fully develop and train?
Thymus
What microbes do T helper cells process?
Extracellular/Exogenous
What microbes do T cytotoxic cells process?
Intracellular/Endogenous
What is considered an extracellular microbe?
Everything except virus
What else do cytotoxic T cells do besides destroy virus-infected host cells?
Destroy tumor cells
What are the two types of dendritic cells?
Regular and Follicular
What is the most important APC?
Dendritic cells
What is the only type of APC that can present antigens to naive T lymphocytes?
Regular dendritic cells
What type of T lymphocyte can B cells and Macrophages present antigens to?
Sensitized helper T cells
What does the activation of T helper cells do?
Activates cytokine synthesis
Where are the antigens presented to T cells by dendritic cells?
Lymph nodes
What dendritic cells stimulate naive T cells?
B7 positive
When does a helper T cell differentiate into further specialized cells?
After activation
What does IL-2 do?
T cell growth factor and induction of activated T helper cell proliferation
What does TH1 do?
Respond to viruses and intravesicular infections
What does TH2 do?
Respond to parasites/allergies
What does TH17 do?
Play a role in recruitment of neutrophils
What does TFH do?
Cause B cell antibody class switching in lymph node
What does TReg do?
Suppress response to prevent autoimmunity
How do helper T cells differentiate into the different TH subjects?
Response to cytokines from APC
What do cytotoxic T cells respond to?
Viruses
What do T gamma-delta lymphocytes respond to?
Mucosal pathogens
What does CD40 ligand do?
Bind to CD40 receptor and stimulate production of more MHC II and B7 molecules
What influences differentiation into Th1 subset?
IL-12 and IFN-gamma
What is IL-12 secreted by?
APCs
What is IFN-gamma secreted by?
Natural Killer cells and T helper cells
What influences differentiation into Th2 cells?
IL-4
What is IL-4 secreted by?
Th2 cells and mast cells
What do Th1 cells secrete?
IFN-gamma and TNF
What does IFN-gamma do?
All of these
Slide 25